Leslie Jhansi L, Young Vincent B
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Curr Opin Microbiol. 2015 Feb;23:121-5. doi: 10.1016/j.mib.2014.11.010. Epub 2014 Dec 2.
Bacterial infectious diseases are studied primarily as a host-pathogen dyad. However it is increasingly apparent that the gut microbial community is an important participant in these interactions. The gut microbiota influences bacterial infections in a number of ways, including via bacterial metabolism, stimulation of host immunity and direct bacterial antagonism. This review focuses on recent findings highlighting the interplay between the gastrointestinal microbiota, its host and bacterial pathogens; and emphasizes how these interactions ultimately impact our understanding of infectious diseases.
细菌感染性疾病主要作为宿主 - 病原体二元组进行研究。然而，越来越明显的是，肠道微生物群落是这些相互作用中的重要参与者。肠道微生物群以多种方式影响细菌感染，包括通过细菌代谢、刺激宿主免疫和直接的细菌拮抗作用。本综述重点关注突出胃肠道微生物群、其宿主和细菌病原体之间相互作用的最新研究结果；并强调这些相互作用如何最终影响我们对传染病的理解。
