在哥伦比亚波哥大的医疗机构发病（HCFO）和社区发病（CO）中心的腹泻患者中，产毒和合并感染的频率较高。
High frequency of toxigenic and coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia.
作者信息
Forero Alex J, Muñoz Marina, Camargo Milena, Soto-De León Sara C, Ríos-Chaparro Dora I, Birchenall Claudia, Pinilla Darío, Pardo Juan M, Josa Diego F, Patarroyo Manuel A, Ramírez Juan D
机构信息
1Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Carrera 24 # 63C - 69, Bogotá, Colombia.
2Especialización en Microbiología Médica, Pontificia Universidad Javeriana, Bogotá, Colombia.
出版信息
Gut Pathog. 2019 Jun 3;11:27. doi: 10.1186/s13099-019-0308-7. eCollection 2019.
BACKGROUND
The aim of this study was to evaluate the frequency of toxigenic and infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests.
RESULTS
We found that 65.5% (n = 144) of the population had infection, followed by toxigenic with 57.3% (n = 126), and finally toxigenic with a frequency of 32.7% (n = 72).
CONCLUSIONS
This study is the first molecular detection and characterization of and in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.
背景
本研究的目的是评估在哥伦比亚波哥大的两个医疗中心，医疗保健机构发病（HCFO）和社区发病（CO）时产毒和感染的频率。通过多种聚合酶链反应（PCR）检测分析了从HCFO或CO获得腹泻症状的患者的总共220份粪便样本。
结果
我们发现65.5%（n = 144）的人群有感染，其次是产毒，占57.3%（n = 126），最后是产毒，频率为32.7%（n = 72）。
结论
本研究是拉丁美洲首次对HCFO和CO中的[具体病原体名称]进行分子检测和鉴定，并证明了这两个物种的相关频率，包括合并感染以及显著不同的产毒谱，尤其是在CO中。
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