Rostama Bahman, Peterson Sarah M, Vary Calvin P H, Liaw Lucy
Center for Molecular Medicine, Maine Medical Center Research Institute, USA.
Vascul Pharmacol. 2014 Nov;63(2):97-104. doi: 10.1016/j.vph.2014.10.003.
Notch signaling plays many important roles in homeostasis and remodeling in the vessel wall, and serves a critical role in the communication between endothelial cells and smooth muscle cells. Within blood vessels, Notch signaling integrates with multiple pathways by mechanisms including direct protein–protein interaction, cooperative or synergistic regulation of signal cascades, and co-regulation of transcriptional targets. After establishment of the mature blood vessel, the spectrum and intensity of Notch signaling change during phases of active remodeling or disease progression. These changes can be mediated by regulation via microRNAs and protein stability or signaling, and corresponding changes in complementary signaling pathways. Notch also affects endothelial cells on a system level by regulating key metabolic components. This review will outline the most recent findings of Notch activity in blood vessels, with a focus on how Notch signals integrate with other molecular signaling pathways controlling vascular phenotype.
Notch信号通路在血管壁的稳态和重塑中发挥着许多重要作用，并且在内皮细胞和平滑肌细胞之间的通讯中起着关键作用。在血管内，Notch信号通路通过包括直接蛋白质-蛋白质相互作用、信号级联的协同或协同调节以及转录靶点的共同调节等机制与多种途径整合。在成熟血管建立后，Notch信号通路的谱和强度在活跃重塑或疾病进展阶段会发生变化。这些变化可通过微小RNA调节、蛋白质稳定性或信号传导以及互补信号通路的相应变化来介导。Notch还通过调节关键代谢成分在系统水平上影响内皮细胞。本综述将概述血管中Notch活性的最新发现，重点关注Notch信号如何与控制血管表型的其他分子信号通路整合。
