Department of Environmental Science and Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, China; Institute of Environmental and Resources Technology, Huaqiao University, Xiamen, Fujian 361021, China.
Department of Environmental Science and Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, China; Institute of Environmental and Resources Technology, Huaqiao University, Xiamen, Fujian 361021, China.
J Hazard Mater. 2015;283:778-86. doi: 10.1016/j.jhazmat.2014.10.026. Epub 2014 Oct 28.
Erythromycin, a macrolide antibiotic, is commonly used in human life. This compound and its derivatives have been detected in various aquatic compartments and may pose a serious threat to aquatic organisms. This study investigated the effects of erythromycin on the growth, antioxidant system and photosynthesis of Microcystis flos-aquae. The results showed that at 0.001-0.1 μg L(-1), erythromycin could stimulate the growth of M. flos-aquae and increase its photosynthetic activity; however, it did not significantly increase the activities of superoxide dismutase (SOD) and catalase (CAT) or the levels of malondialdehyde (MDA) and reactive oxygen species (ROS). In contrast, the growth of M. flos-aquae was significantly inhibited (p<0.01) at high levels of erythromycin, reaching an inhibition rate of 81.6% at 40 μg L(-1) erythromycin. At the same time, the activities of SOD and CAT along with MDA content also increased significantly (p<0.01), indicating that the high concentrations of erythromycin caused a severe oxidative stress on algae. However, the balance between oxidants and antioxidant enzymes were disrupted because ROS content simultaneously increased. In addition, the fluorescence parameters of M. flos-aquae decreased significantly with both exposure time and increasing concentration of erythromycin, indicating that photosynthesis was inhibited.
红霉素是一种大环内酯类抗生素，在人类生活中被广泛使用。该化合物及其衍生物已在各种水生环境中被检出，可能对水生生物构成严重威胁。本研究考察了红霉素对铜绿微囊藻生长、抗氧化系统和光合作用的影响。结果表明，在 0.001-0.1μg/L 浓度范围内，红霉素能刺激铜绿微囊藻生长，提高其光合活性；但对超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性及丙二醛（MDA）和活性氧（ROS）水平无显著影响。相比之下，高浓度红霉素（40μg/L）显著抑制铜绿微囊藻生长，抑制率达 81.6%。同时，SOD 和 CAT 活性及 MDA 含量也显著升高（p<0.01），表明高浓度红霉素对藻类造成严重的氧化胁迫。然而，由于 ROS 含量同时增加，氧化剂和抗氧化酶之间的平衡被打破。此外，铜绿微囊藻的荧光参数随红霉素暴露时间和浓度的增加而显著下降，表明光合作用受到抑制。
