鸟嘌呤核苷酸刺激人髓鞘膜中磷脂酰肌醇二磷酸的水解。
Guanine nucleotides stimulate hydrolysis of phosphatidyl inositol bis phosphate in human myelin membranes.
作者信息
Boulias C, Moscarello M A
机构信息
Hospital for Sick Children, Department of Biochemistry, Toronto, Ontario, Canada.
出版信息
Biochem Biophys Res Commun. 1989 Jul 14;162(1):282-7. doi: 10.1016/0006-291x(89)91993-1.
Phosphodiesterase activity was stimulated in myelin membranes in the presence of guanine nucleotide analogues. This activity was reduced in myelin membranes which had been adenosine diphosphate ribosylated in the presence of cholera toxin which ADP-ribosylated three proteins of Mr 46,000, 43,000 and 18,500. Aluminum fluoride treatment of myelin had the same stimulatory effects on phosphodiesterase activity as did the guanine nucleotides.
在鸟嘌呤核苷酸类似物存在的情况下，髓磷脂膜中的磷酸二酯酶活性受到刺激。在霍乱毒素存在下进行了二磷酸腺苷核糖基化的髓磷脂膜中，这种活性降低了，霍乱毒素使分子量为46,000、43,000和18,500的三种蛋白质发生了ADP核糖基化。用氟化铝处理髓磷脂对磷酸二酯酶活性具有与鸟嘌呤核苷酸相同的刺激作用。
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