南亚人群身体成分与胱抑素C之间的关联：MASALA研究结果
The association between body composition and cystatin C in South Asians: results from the MASALA study.
作者信息
Shah Arti D, Schmidt Heidi, Sen Saunak, Shlipak Michael G, Kanaya Alka M
机构信息
Division of Endocrinology and Metabolism, University of California, San Francisco, United States.
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, United States.
出版信息
Obes Res Clin Pract. 2015 Mar-Apr;9(2):180-3. doi: 10.1016/j.orcp.2014.10.221. Epub 2014 Nov 18.
While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFRcysC) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFRcysC was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation.
虽然南亚人的肥胖率和肾病发病率较高，但关于区域身体成分对肾功能的影响却知之甚少。我们调查了150名南亚移民的身体成分测量指标与基于胱抑素C的估计肾小球滤过率（eGFRcysC）之间的关联。总体肥胖与eGFRcysC之间的负相关关系被C反应蛋白（CRP）减弱，而异位脂肪的关联则被代谢协变量和CRP完全减弱。在南亚移民中，总体肥胖和异位脂肪与肾功能下降之间的关联很大程度上可由代谢改变和炎症来解释。
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