Department of Bioengineering and Institute for Biotechnology and Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001 Lisboa, Portugal.
Department of Bioengineering and Institute for Biotechnology and Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001 Lisboa, Portugal.
Trends Biotechnol. 2015 Jan;33(1):35-42. doi: 10.1016/j.tibtech.2014.11.003. Epub 2014 Nov 29.
Advanced cell-based therapies are promising approaches for stimulating full regeneration of cartilage lesions. In addition to a few commercially available medicinal products, several clinical and preclinical studies are ongoing worldwide. In preclinical settings, high-quality cartilage tissue has been produced using combination strategies involving stem or progenitor cells, biomaterials, and biomolecules to generate a construct for implantation at the lesion site. Cell numbers and mechanical stimulation of the constructs are not commonly considered, but are important parameters to be evaluated in forthcoming clinical studies. We review current clinical and preclinical studies for advanced therapy cartilage regeneration and evaluate the progress of the field.
先进的基于细胞的疗法是刺激软骨损伤完全再生的有前途的方法。除了少数几种市售的医药产品外，全世界还有许多临床前和临床研究正在进行。在临床前环境中，已经使用涉及干细胞或祖细胞、生物材料和生物分子的组合策略来生产高质量的软骨组织，以生成用于在病变部位植入的构建体。细胞数量和构建体的机械刺激通常不被考虑，但在即将进行的临床研究中是需要评估的重要参数。我们回顾了先进的治疗软骨再生的临床前和临床研究，并评估了该领域的进展。
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