经颅直流电刺激的刺激强度在儿童和青少年中必须进行调整。
Stimulation intensities of transcranial direct current stimulation have to be adjusted in children and adolescents.
作者信息
Moliadze Vera, Schmanke Till, Andreas Saskia, Lyzhko Ekaterina, Freitag Christine M, Siniatchkin Michael
机构信息
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe-University Frankfurt am Main, Deutschordenstr. 50, D-60528 Frankfurt am Main, Germany; Department of Medical Psychology and Medical Sociology, Schleswig-Holstein University Hospital (UK-SH), Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe-University Frankfurt am Main, Deutschordenstr. 50, D-60528 Frankfurt am Main, Germany.
出版信息
Clin Neurophysiol. 2015 Jul;126(7):1392-9. doi: 10.1016/j.clinph.2014.10.142. Epub 2014 Oct 28.
OBJECTIVE
The aim of the present study was to investigate the effect of the transcranial direct current stimulation (tDCS) on motor cortex excitability in healthy children and adolescents.
METHODS
We applied 1mA anodal or cathodal tDCS for 10min on the left primary motor cortex of 19 healthy children and adolescents (mean age 13.9±0.4years). In order to prove whether the effects of tDCS may be attributed to the stimulation intensity, 10 children and adolescents were studied again using 0.5mA anodal and cathodal tDCS. Sham stimulation was used as a control.
RESULTS
Compared with sham stimulation, both 1mA anodal and cathodal tDCS resulted in a significant increase of Motor evoked potentials (MEP) amplitudes which remained to be prominent even one hour after the end of stimulation. Interestingly, the 0.5mA cathodal tDCS decreased cortico-spinal excitability whereas the 0.5mA anodal stimulation did not result in any effect.
CONCLUSION
For the first time, the study demonstrates age-specific influences of tDCS on cortical excitability of the primary motor cortex.
SIGNIFICANCE
Thus, the stimulation protocols of the tDCS have to be optimized according to age by planning studies in pediatric population.
目的
本研究旨在探讨经颅直流电刺激（tDCS）对健康儿童和青少年运动皮层兴奋性的影响。
方法
我们对19名健康儿童和青少年（平均年龄13.9±0.4岁）的左侧初级运动皮层施加1mA阳极或阴极tDCS，持续10分钟。为了证明tDCS的效果是否可能归因于刺激强度，我们再次对10名儿童和青少年使用0.5mA阳极和阴极tDCS进行研究。假刺激作为对照。
结果
与假刺激相比，1mA阳极和阴极tDCS均导致运动诱发电位（MEP）幅度显著增加，即使在刺激结束后一小时仍保持显著。有趣的是，0.5mA阴极tDCS降低了皮质脊髓兴奋性，而0.5mA阳极刺激未产生任何影响。
结论
该研究首次证明了tDCS对初级运动皮层皮质兴奋性具有年龄特异性影响。
意义
因此，必须通过在儿科人群中开展研究，根据年龄优化tDCS的刺激方案。
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