1 mA 阴极经颅直流电刺激在儿童和青少年中表现出兴奋作用：来自 TMS 诱发 N100 电位的见解。
1 mA cathodal tDCS shows excitatory effects in children and adolescents: Insights from TMS evoked N100 potential.
机构信息
Institute of Medical Psychology and Medical Sociology, University Hospital of Schleswig-Holstein (UKSH), Campus Kiel, Christian-Albrechts-University Kiel, Preußerstrasse 1-9, 24105, Kiel, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy Goethe-University, Deutschordenstr, 50, D-60528, Frankfurt am Main, Germany.
Institute of Medical Psychology and Medical Sociology, University Hospital of Schleswig-Holstein (UKSH), Campus Kiel, Christian-Albrechts-University Kiel, Preußerstrasse 1-9, 24105, Kiel, Germany.
出版信息
Brain Res Bull. 2018 Jun;140:43-51. doi: 10.1016/j.brainresbull.2018.03.018. Epub 2018 Apr 3.
In children and adolescents, 1 mA transcranial direct current stimulation (tDCS) may cause "paradoxical" effects compared with adults: both 1 mA anodal and cathodal tDCS increase amplitude of the motor evoked potential (MEP) as revealed by a single pulse transcranial magnetic stimulation (TMS) of the motor cortex. Here, EEG based evoked potentials induced by a single pulse TMS, particularly the N100 component as marker of motor cortex inhibition, were investigated in order to explain effects of tDCS on the developing brain. In nineteen children and adolescents (11-16 years old), 1 mA anodal, cathodal, or sham tDCS was applied over the left primary motor cortex for 10 min. The TMS-evoked N100 was measured by 64-channel EEG before and immediately after stimulation as well as every 10 min after tDCS for one hour. 1 mA Cathodal stimulation suppressed the N100 amplitude compared with sham stimulation. In contrast, anodal tDCS did not modify the N100 amplitude. It seems likely that the increase of the motor cortex activity under cathodal tDCS in children and adolescents as shown in previous studies can be attributed to a reduce inhibition. Based on TMS evoked N100, the study provides an insight into neuromodulatory effects of tDCS on the developing brain.
在儿童和青少年中，与成年人相比，1 mA 的经颅直流电刺激 (tDCS) 可能会产生“反常”的效果：单次经颅磁刺激 (TMS) 刺激运动皮层时，1 mA 的阳极和阴极 tDCS 都会增加运动诱发电位 (MEP) 的幅度。在此，研究了单次 TMS 诱发的基于 EEG 的诱发电位，特别是作为运动皮层抑制标志物的 N100 成分，以解释 tDCS 对发育中大脑的影响。在 19 名儿童和青少年（11-16 岁）中，将 1 mA 的阳极、阴极或假 tDCS 应用于左初级运动皮层 10 分钟。在刺激之前和之后立即以及 tDCS 后每 10 分钟一次，通过 64 通道 EEG 测量 TMS 诱发的 N100。与假刺激相比，1 mA 阴极刺激抑制了 N100 幅度。相比之下，阳极 tDCS 并未改变 N100 幅度。阴极 tDCS 下运动皮层活动的增加似乎可以归因于抑制作用的降低。基于 TMS 诱发的 N100，该研究深入了解了 tDCS 对发育中大脑的神经调节作用。
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