除（18）F-FDG之外的正电子发射断层显像（PET）探针。
PET probes beyond (18)F-FDG.
作者信息
Jiang Lei, Tu Yingfeng, Shi Hongcheng, Cheng Zhen
机构信息
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. ; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford Cancer Institute, Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA 94305, USA.
Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford Cancer Institute, Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA 94305, USA.
出版信息
J Biomed Res. 2014 Nov;28(6):435-46. doi: 10.7555/JBR.28.20130196. Epub 2014 Apr 15.
During the past several decades, positron emission tomography (PET) has been one of the rapidly growing areas of medical imaging; particularly, its applications in routine oncological practice have been widely recognized. At present, (18)F-fluorodeoxyglucose ((18)F-FDG) is the most broadly used PET probe. However, (18)F-FDG also suffers many limitations. Thus, scientists and clinicians are greatly interested in exploring and developing new PET imaging probes with high affinity and specificity. In this review, we briefly summarize the representative PET probes beyond (18)F-FDG that are available for patients imaging in three major clinical areas (oncology, neurology and cardiology), and we also discuss the feasibility and trends in developing new PET probes for personalized medicine.
在过去几十年中，正电子发射断层扫描（PET）一直是医学成像领域中快速发展的领域之一；特别是，其在常规肿瘤学实践中的应用已得到广泛认可。目前，（18）F-氟脱氧葡萄糖（（18）F-FDG）是使用最广泛的PET探针。然而，（18）F-FDG也存在许多局限性。因此，科学家和临床医生对探索和开发具有高亲和力和特异性的新型PET成像探针非常感兴趣。在这篇综述中，我们简要总结了除（18）F-FDG之外的代表性PET探针，这些探针可用于三大临床领域（肿瘤学、神经病学和心脏病学）的患者成像，并且我们还讨论了开发用于个性化医疗的新型PET探针的可行性和趋势。
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