Mardani Maryam, Andisheh-Tadbir Azadeh, Khademi Bijan, Biparva Peyman, Malekzadeh Mahyar
Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dent (Shiraz). 2014 Dec;15(4):199-203.
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of certain diseases and cancers via tissue destruction and can be secreted into the blood stream. MMP9 expression in the salivary gland tissue was evaluated but their serum level in the salivary gland tumors was not studied.
The aim of our study was to determine the concentration of serum MMP-9 in healthy participants and in patients with salivary gland tumor.
Using an ELISA kit, the circulating levels of MMP-9 in sera from 58 patients with salivary gland tumor (31 pleomorphic adenoma, 17 adenoid cystic carcinoma and 10 mucoepidermoid carcinoma) and 30 healthy controls was assessed.
The serum MMP9 level in patients with salivary gland tumors (380.0±301.3 pg/ml) also patients with benign tumors (354.3±218.7 pg/ml) (354.3±218.7 pg/ml) were significantly lower than that in the healthy group (727.4±624.6 pg/ml) (Respectively p= 0.02 and p= 0.01). Mean serum MMP9 concentration in malignant tumors was (402.3±441.8pg/ml) higher than benign tumors (354.3±218.7 pg/ml) but the difference was not significant (p= 0.9).
Our results showed that serum level of MMP9 decreased in patients with salivary gland tumors which suggest that MMP9 may not have a potential role in development and pathogenesis of salivary gland tumor.
基质金属蛋白酶（MMPs）通过组织破坏参与某些疾病和癌症的发病机制，并可分泌到血流中。已对唾液腺组织中的MMP9表达进行了评估，但未研究其在唾液腺肿瘤中的血清水平。
我们研究的目的是确定健康参与者和唾液腺肿瘤患者血清MMP-9的浓度。
使用ELISA试剂盒，评估了58例唾液腺肿瘤患者（31例多形性腺瘤、17例腺样囊性癌和10例黏液表皮样癌）和30名健康对照者血清中MMP-9的循环水平。
唾液腺肿瘤患者的血清MMP9水平（380.0±301.3 pg/ml）以及良性肿瘤患者的血清MMP9水平（354.3±218.7 pg/ml）均显著低于健康组（727.4±624.6 pg/ml）（分别为p = 0.02和p = 0.01）。恶性肿瘤患者的血清MMP9平均浓度（402.3±441.8 pg/ml）高于良性肿瘤患者（354.3±218.7 pg/ml），但差异不显著（p = 0.9）。
我们的结果表明，唾液腺肿瘤患者的血清MMP9水平降低，这表明MMP9可能在唾液腺肿瘤的发生和发病机制中不具有潜在作用。
