Vincent Corita, Hall Peter A
From the University of Waterloo (C.V., P.A.H.), Waterloo, Ontario, Canada.
Psychosom Med. 2015 Jul-Aug;77(6):631-42. doi: 10.1097/PSY.0000000000000103.
To examine the extent to which Type 2 diabetes mellitus (T2DM) is associated with impairments in executive function (EF).
Medline, PsychoInfo, and Scopus databases and published references were used to identify articles examining the association between T2DM status (case versus control) and EF decrements. Results from studies were converted to standardized mean differences and compared using random-effects models. Moderator analysis was conducted for age, sex, and diabetes duration using maximum likelihood estimation.
Sixty studies (59 articles) including 9815 individuals with T2DM and 69,254 controls were included. Findings indicated a small but reliable association between T2DM status and EF decrements (d = -0.248, p < .001), observed across all aspects of EF examined: verbal fluency, mental flexibility, inhibition, working memory, and attention. Disease duration significantly moderated the effect of T2DM status on EF.
T2DM is associated with a mild-to-moderate EF decrements. Such decrements are stronger among those with shorter disease duration.
探讨2型糖尿病（T2DM）与执行功能（EF）受损之间的关联程度。
利用Medline、PsychoInfo和Scopus数据库以及已发表的参考文献，筛选出研究T2DM状态（病例组与对照组）与EF减退之间关联的文章。将研究结果转换为标准化均数差，并使用随机效应模型进行比较。采用最大似然估计法对年龄、性别和糖尿病病程进行调节分析。
纳入60项研究（59篇文章），共9815例T2DM患者和69254例对照。结果表明，T2DM状态与EF减退之间存在小但可靠的关联（d = -0.248，p <.001），在EF的各个方面均有体现：语言流畅性、心理灵活性、抑制能力、工作记忆和注意力。病程显著调节了T2DM状态对EF的影响。
T2DM与轻度至中度的EF减退有关。在病程较短的患者中，这种减退更为明显。
