Hinson J P, Vinson G P, Pudney J, Whitehouse B J
Department of Biochemistry, St Bartholomew's Hospital Medical College, London.
J Endocrinol. 1989 May;121(2):253-60. doi: 10.1677/joe.0.1210253.
Mast cells were identified in the rat adrenal gland, located in the walls of arterioles at the point at which they penetrate the connective tissue capsule. The mast cell products, histamine and serotonin, both caused dose-dependent increases in rates of perfusion medium flow and steroid secretion in the isolated, perfused rat adrenal gland in situ. Compound 48-80, a mast cell degranulator, caused a significant increase in perfusion medium flow rate and steroid secretion by the in-situ perfused rat adrenal. Administration of disodium cromoglycate, a mast cell stabilizer, before administration of ACTH(1-24) virtually abolished the normal flow rate increment and significantly attenuated the corticosterone secretory response to ACTH(1-24). These observations strongly suggest that adrenal mast cells modulate both vascular and secretory responses in the intact adrenal gland of the rat.
在大鼠肾上腺中发现了肥大细胞，它们位于小动脉壁上，此处小动脉穿透结缔组织被膜。肥大细胞产物组胺和5-羟色胺，均可使离体原位灌注的大鼠肾上腺中灌注液流速和类固醇分泌率呈剂量依赖性增加。化合物48-80是一种肥大细胞脱颗粒剂，可使原位灌注的大鼠肾上腺的灌注液流速和类固醇分泌显著增加。在给予促肾上腺皮质激素（1-24）之前给予肥大细胞稳定剂色甘酸二钠，几乎消除了正常的流速增加，并显著减弱了对促肾上腺皮质激素（1-24）的皮质酮分泌反应。这些观察结果有力地表明，肾上腺肥大细胞调节大鼠完整肾上腺中的血管和分泌反应。
