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具有临床意义的耳鸣发病率:来自英国一项队列研究的10年趋势

Incidence rates of clinically significant tinnitus: 10-year trend from a cohort study in England.

作者信息

Martinez Carlos, Wallenhorst Christopher, McFerran Don, Hall Deborah A

机构信息

1Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany; 2Colchester Hospital University NHS Foundation Trust, Colchester, Essex, United Kingdom; 3National Institute for Health Research (NIHR) Nottingham Hearing Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom; and 4Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

出版信息

Ear Hear. 2015 May-Jun;36(3):e69-75. doi: 10.1097/AUD.0000000000000121.

Abstract

OBJECTIVE

To investigate the incidence of tinnitus that burdens the health service in England.

DESIGN

This was an observational study of 4.7 million residents of England under 85 years of age who were at risk for developing clinically significant tinnitus (sigT). SigT was defined by a discharge from hospital with a primary diagnosis of tinnitus, or a primary care recording of tinnitus with subsequent related medical follow-up within 28 days. The database used was the Clinical Practice Research Datalink and individual records were linked to additional data from the Hospital Episode Statistics. The observational period was from January 1, 2002 to December 31, 2011. Age-, gender-, and calendar year-specific incidence rates for and cumulative incidences of sigT were estimated and a projection of new cases of sigT between 2012 and 2021 was performed.

RESULTS

There were 14,303 incident cases of sigT identified among 26.5 million person-years of observation. The incidence rate was 5.4 new cases of sigT per 10,000 person-years (95% confidence interval: 5.3 to 5.5). The incidence rate did not depend on gender but increased with age, peaking at 11.4 per 10,000 in the age group 60 to 69 years. The annual incidence rate of sigT increased from 4.5 per 10,000 person-years in 2002 to 6.6 per 10,000 person-years in 2011. The 10-year cumulative incidence of sigT was 58.4 cases (95% confidence interval: 57.4 to 59.4) per 10,000 residents. Nearly 324,000 new cases of sigT are expected to occur in England between 2012 and 2021.

CONCLUSIONS

Tinnitus presents a burden to the health care system that has been rising in recent years. Population-based studies provide crucial underpinning evidence; highlighting the need for further research to address issues around effective diagnosis and clinical management of this heterogeneous condition.

摘要

目的

调查给英国医疗服务带来负担的耳鸣发病率。

设计

这是一项对470万85岁以下有患临床显著耳鸣(sigT)风险的英国居民进行的观察性研究。sigT的定义为医院出院记录中主要诊断为耳鸣,或初级保健记录中有耳鸣且随后在28天内有相关医疗随访。所使用的数据库是临床实践研究数据链,个人记录与医院事件统计的其他数据相链接。观察期为2002年1月1日至2011年12月31日。估计了特定年龄、性别和日历年的sigT发病率及累积发病率,并对2012年至2021年sigT新病例进行了预测。

结果

在2650万人年的观察中,共识别出14303例sigT发病病例。发病率为每10000人年5.4例新的sigT病例(95%置信区间:5.3至5.5)。发病率与性别无关,但随年龄增长而增加,在60至69岁年龄组达到峰值,为每10000人年11.4例。sigT的年发病率从2002年的每10000人年4.5例增至2011年的每10000人年6.6例。sigT的10年累积发病率为每10000居民58.4例(95%置信区间:57.4至59.4)。预计2012年至2021年英国将出现近324000例新的sigT病例。

结论

耳鸣给医疗保健系统带来负担,且近年来负担一直在增加。基于人群的研究提供了关键的基础证据;凸显了进一步研究以解决围绕这种异质性疾病的有效诊断和临床管理问题的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0818/4415963/d2d50e4e561a/aud-36-e69-g001.jpg

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