Ohland Christina L, Jobin Christian
Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
Department of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32610, USA.
Cell Metab. 2014 Dec 2;20(6):937-8. doi: 10.1016/j.cmet.2014.11.010.
Obesity and the associated state of subchronic inflammation are risk factors for numerous pathologies, including carcinogenesis. Recently, Schulz et al. (2014) demonstrated that high-fat diet-induced intestinal dysbiosis promotes cancer development in K-ras(G12Dint) mice without inducing obesity or mucosal inflammation, positioning microbial activities as a central component of diet-induced carcinogenesis.
肥胖以及相关的亚慢性炎症状态是包括致癌作用在内的多种病症的风险因素。最近，舒尔茨等人（2014年）证明，高脂饮食诱导的肠道微生物失调会促进携带K-ras（G12Dint）基因的小鼠发生癌症，且不会导致肥胖或黏膜炎症，这表明微生物活动是饮食诱导致癌作用的核心组成部分。
