Sebestyén A, Mester S, Vokó Z, Gajdácsi J, Cserháti P, Speer G, Patczai B, Warta V, Bódis J, Horváth C, Boncz I
South-Transdanubian Regional Office, National Health Insurance Fund Administration, Pécs, Nagy Lajos király út 3, H-7623, Hungary,
Osteoporos Int. 2015 Mar;26(3):1109-17. doi: 10.1007/s00198-014-2966-0. Epub 2014 Dec 4.
The study demonstrates that wintertime surgeries are associated with impaired fracture healing and increases the risk of conversion to hip arthroplasty after osteosynthesis of femoral neck fracture. Furthermore, the results raise the possibility of association between seasonal changes in vitamin D levels and impaired fracture healing of femoral neck fracture.
Although the changes of vitamin D level and calcitropic hormones influencing bone metabolism are seasonal, the effect of seasons on hip fracture healing is unknown. We assessed the effects of seasonal periodicity on conversion to hip arthroplasty after primary osteosynthesis of femoral neck fracture.
This nationwide retrospective observational cohort study involved 2779 patients aged ≥ 60 years who underwent internal screw fixation for primary femoral neck fracture and were discharged in 2000. Cases requiring conversion to arthroplasty during the 8-year follow-up derived from the Hungarian health insurance database were registered. Risk factors assessed included sex, age, fracture type, season of primary surgery and surgical delay. Competing-risks regression analysis was used for data analyses.
During the observation period, 190 conversions to hip arthroplasty (6.8%) were identified, yielding an overall incidence of 19.5 per 1000 person-years. The crude incidence rates of conversions after osteosynthesis in winter, spring, summer and fall were 28.6, 17.8, 16.9 and 14.7 per 1000 person-years, respectively. Besides younger age, female sex and intracapsular fracture displacement, wintertime primary osteosynthesis significantly increased the risk of conversion (fall vs. winter, hazard ratio (HR): 0.50, 95% confidence interval [95% CI 0.33-0.76]; spring vs. winter, HR: 0.63, [95% CI 0.44-0.92]; summer vs. winter, HR: 0.62, [95% CI 0.42-0.91]).
Our study demonstrate that wintertime primary osteosynthesis increases the risk of conversion surgeries. The results may help improving the outcome of primary fixation of femoral neck fractures.
该研究表明,冬季手术与骨折愈合受损相关,并增加了股骨颈骨折内固定术后转为髋关节置换术的风险。此外,研究结果增加了维生素D水平的季节性变化与股骨颈骨折愈合受损之间存在关联的可能性。
尽管影响骨代谢的维生素D水平和促钙激素的变化具有季节性,但季节对髋部骨折愈合的影响尚不清楚。我们评估了季节性周期对股骨颈骨折初次内固定术后转为髋关节置换术的影响。
这项全国性回顾性观察队列研究纳入了2779例年龄≥60岁、2000年因股骨颈骨折初次行内固定术并出院的患者。从匈牙利健康保险数据库中记录了在8年随访期间需要转为关节置换术的病例。评估的危险因素包括性别、年龄、骨折类型、初次手术季节和手术延迟。采用竞争风险回归分析进行数据分析。
在观察期内,共确定了190例转为髋关节置换术的病例(6.8%),总发病率为每1000人年19.5例。冬季、春季、夏季和秋季内固定术后转为关节置换术的粗发病率分别为每1000人年28.6例、17.8例、16.9例和14.7例。除了年龄较小、女性和囊内骨折移位外,冬季初次内固定术显著增加了转为关节置换术的风险(秋季与冬季相比,风险比(HR):0.50,95%置信区间[95%CI 0.33-0.76];春季与冬季相比,HR:0.63,[95%CI 0.44-0.92];夏季与冬季相比,HR:0.62,[95%CI 0.42-0.91])。
我们的研究表明,冬季初次内固定术会增加转为关节置换术的风险。这些结果可能有助于改善股骨颈骨折初次固定的疗效。