基于单条G-四链体DNA链的多种类型逻辑门
Multiple types of logic gates based on a single G-quadruplex DNA strand.
作者信息
Guo Yahui, Zhou Lu, Xu Lijun, Zhou Xiaodong, Hu Jiming, Pei Renjun
机构信息
1] Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China) [2] Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry &Molecular Sciences, Wuhan University, Wuhan, 430072 (China).
Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 (China).
出版信息
Sci Rep. 2014 Dec 4;4:7315. doi: 10.1038/srep07315.
In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K(+), thrombin, Hg(2+), and Pb(2+)) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.
在本研究中，我们展示了使用单链DNA和G-四链体特异性染料NMM作为无标记开关，构建一系列基本逻辑门（是、非、或、抑制、或非、与）。富含GT的简单序列可用于与多种分子（K⁺、凝血酶、Hg²⁺和Pb²⁺）相互作用，形成不同结构，这些结构可通过无标记染料NMM进行区分。我们的研究表明，单条G-四链体DNA链可以作为多种类型的单输入和双输入逻辑门，具有不同的输入分子组合。
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