Zeidabadi Afsaneh, Yazdanpanahi Zahra, Dabbaghmanesh Mohammad Hossain, Sasani Mohammad Resa, Emamghoreishi Masoumeh, Akbarzadeh Marzieh
Community Based Psychiatric Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Endocrinology, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Family Med Prim Care. 2020 Feb 28;9(2):1086-1092. doi: 10.4103/jfmpc.jfmpc_913_19. eCollection 2020 Feb.
Complications of hormone therapy (as replacement) during menopause prompted us to research on alternative therapies including herbal therapy in this regard.
The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women on Namazi Hospital Bone Density Center in Shiraz 2015.
In a double-blind randomized controlled clinical trial, 66 postmenopausal women complaining of menopausal symptoms were divided into two groups of intervention and control, respectively. The intervention group received S. officinalis tablets (containing 100 mg S. officinalis extract), with a dose of three tablets a day for 3 months, while the control group received placebo tablets with the same prescription order. MRS (Menopause Rating Scale) and PSQI (Pittsburgh Sleep Quality Index) questionnaires were completed at the beginning and end of the study. The checklists of hot flushing and night sweating were completed a week before the intervention and at weeks 2, 4, 6, 8, 10, 12 during the intervention. Finally, the data were analyzed through SPSS software, using paired -test, ANOVA. A significant level of 5% was considered.
According to the paired -test, the mean score of flushing, palpitation, sleeping disorders, muscle and joint aches, depression, nervousness, anxiety, and sexual desire and satisfaction significantly decreased by 1.6, 0.4, 1.6, 2.1, 1.4, 1.2, 1.6, and 0.8 units, respectively, in the intervention group compared to the control group ( < 0.001). Therefore, the mean score of PSQI significantly decreased by 3.8 units in the intervention group after the intervention (9.4 ± 3.7 vs 5.6 ± 1.9 ( < 0.05).
Salvia extract improved menopausal symptoms such as flushing, night sweat, heart palpitations, muscle and joint pain, depression, anxiety, sleep disorders, and sexual desire.
更年期激素替代疗法的并发症促使我们研究包括草药疗法在内的替代疗法。
2015年在设拉子纳马齐医院骨密度中心研究鼠尾草提取物对绝经后妇女潮热、盗汗、睡眠障碍及健忘评分的影响。
在一项双盲随机对照临床试验中，66名主诉更年期症状的绝经后妇女分别分为干预组和对照组。干预组服用鼠尾草片（含100毫克鼠尾草提取物），剂量为每日三片，共3个月，而对照组服用相同处方顺序的安慰剂片。在研究开始和结束时完成更年期评定量表（MRS）和匹兹堡睡眠质量指数（PSQI）问卷。潮热和盗汗检查表在干预前一周以及干预期间的第2、4、6、8、10、12周完成。最后，通过SPSS软件使用配对检验、方差分析对数据进行分析。显著性水平设定为5%。
根据配对检验，与对照组相比，干预组的潮热、心悸、睡眠障碍、肌肉和关节疼痛、抑郁、紧张、焦虑以及性欲和满意度的平均得分分别显著降低了1.6、0.4、1.6、2.1、1.4、1.2、1.6和0.8个单位（<0.001）。因此，干预后干预组的PSQI平均得分显著降低了3.8个单位（9.4±3.7对5.6±1.9（<0.05）。
鼠尾草提取物改善了潮热、盗汗、心悸、肌肉和关节疼痛、抑郁、焦虑、睡眠障碍以及性欲等更年期症状。
