健康成年人黄斑色素光密度与氧化型低密度脂蛋白血清浓度的关联。

Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults.

作者信息

Nagai Norihiro, Izumi-Nagai Kanako, Suzuki Misa, Shinoda Hajime, Koto Takashi, Uchida Atsuro, Mochimaru Hiroshi, Tomita Yohei, Miyake Seiji, Kobayashi Saori, Sasaki Mariko, Tsubota Kazuo, Ozawa Yoko

机构信息

*Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan; †Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; and ‡Wakasa Seikatsu Corporation, Kyoto, Japan.

出版信息

Retina. 2015 Apr;35(4):820-6. doi: 10.1097/IAE.0000000000000382.

DOI:10.1097/IAE.0000000000000382

PMID:25473786

Abstract

PURPOSE

To analyze the association between macular pigment optical density (MPOD), which reflects lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) in the macula, and background characteristics.

METHODS

Fifty-five healthy adult volunteers were analyzed. Macular pigment optical density was measured using a heterochromatic flicker photometry technique, and serum concentrations of carotenoids and lipoproteins were by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. Dietary intake of nutrient was determined by a validated self-administered questionnaire on ingestion frequency.

RESULTS

Macular pigment optical density was positively correlated with serum concentrations of L and Z and dietary L intake and inversely correlated with serum oxidized low-density lipoprotein (LDL). Although MPOD decreased with age (95% confidence interval, -0.011 to -0.002; correlation coefficient, -0.269; P = 0.007), serum L/Z and dietary L intake did not. In contrast, serum oxidized LDL was positively correlated with age (95% confidence interval, 0.69-2.34; correlation coefficient, 0.333; P = 0.0004). After adjusting for age, sex, and oxidized LDL, serum L was positively correlated with MPOD (95% confidence interval, 0.88-1.69; P = 0.000001). After adjusting for age, sex, and serum L, serum oxidized LDL was inversely correlated with MPOD (95% confidence interval, -0.002 to -0.0004; P = 0.006).

CONCLUSION

Macular pigment optical density was inversely correlated with serum oxidized LDL. Further study to know the impact of oxidized LDL on MPOD may be warranted.

摘要

目的

分析反映黄斑中叶黄素（L）、玉米黄质（Z）和内消旋玉米黄质（MZ）的黄斑色素光密度（MPOD）与背景特征之间的关联。

方法

对55名健康成年志愿者进行分析。使用异色闪烁光度法测量黄斑色素光密度，分别通过高效液相色谱法和酶联免疫吸附测定法测定血清类胡萝卜素和脂蛋白浓度。通过一份经过验证的关于摄入频率的自填问卷确定营养素的饮食摄入量。

结果

黄斑色素光密度与血清L和Z浓度以及饮食中L摄入量呈正相关，与血清氧化型低密度脂蛋白（LDL）呈负相关。尽管MPOD随年龄下降（95%置信区间，-0.011至-0.002；相关系数，-0.269；P = 0.007），但血清L/Z和饮食中L摄入量并未下降。相比之下，血清氧化型LDL与年龄呈正相关（95%置信区间，0.69 - 2.34；相关系数，0.333；P = 0.0004）。在调整年龄、性别和氧化型LDL后，血清L与MPOD呈正相关（95%置信区间，0.88 - 1.69；P = 0.000001）。在调整年龄、性别和血清L后，血清氧化型LDL与MPOD呈负相关（95%置信区间，-0.002至-0.0004；P = 0.006）。