School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Yunnan Cancer Hospital (Third Affiliated Hospital of Kunming Medical University), Kunming, Yunnan 650118, P.R. China.
Oncol Rep. 2024 Sep;52(3). doi: 10.3892/or.2024.8782. Epub 2024 Jul 26.
Ferroptosis inducers (FIN) have a key role in cancer therapy and provide novel and innovative treatment strategies. Although many researchers have performed FIN screening of synthetic compounds, studies on the identification of FIN from natural products are limited, particularly in the field of drug development and combination therapy. In this review, this gap was addressed by comprehensively summarizing recent studies on ferroptosis. The causes of ferroptosis were categorized into driving and defensive factors, elucidating key pathways and targets. Next, through summarizing research on natural products that induce ferroptosis, the study elaborated in detail on the natural products that have FIN functions. Their discovery and development were also described and insight for clinical drug development was provided. In addition, the mechanisms of action were analyzed and potential combination therapies, resistance reversal and structural enhancements were presented. By highlighting the potential of natural products in inducing ferroptosis for cancer treatment, this review may serve as a reference for utilizing these compounds against cancer. It not only showed the significance of natural products but may also promote further investigation into their therapeutic effects, thus encouraging research in this field.
铁死亡诱导剂（FIN）在癌症治疗中具有关键作用，并提供了新颖和创新的治疗策略。尽管许多研究人员已经对合成化合物进行了 FIN 筛选，但对天然产物中 FIN 的鉴定研究有限，特别是在药物开发和联合治疗领域。在这篇综述中，通过全面总结铁死亡的最新研究，弥补了这一空白。铁死亡的原因分为驱动因素和防御因素，阐明了关键途径和靶点。接下来，通过总结诱导铁死亡的天然产物研究，详细阐述了具有 FIN 功能的天然产物。还描述了它们的发现和开发，并为临床药物开发提供了见解。此外，还分析了作用机制，并提出了潜在的联合治疗、耐药逆转和结构增强。通过强调天然产物在诱导铁死亡治疗癌症方面的潜力，本文可为利用这些化合物治疗癌症提供参考。它不仅显示了天然产物的重要性，而且可能促进对其治疗效果的进一步研究，从而鼓励该领域的研究。
