Pillai-Kastoori Lakshmi, Wen Wen, Morris Ann C
Department of Biology, University of Kentucky, Lexington, Kentucky, USA.
Dev Dyn. 2015 Mar;244(3):367-376. doi: 10.1002/dvdy.24235. Epub 2014 Dec 21.
The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate. In this review article, we provide an overview of stages of embryonic eye morphogenesis, extrinsic and intrinsic factors that are required for each stage, and pediatric ocular diseases that are associated with defective eye development. In addition, we focus on recent findings about the roles of the SOXC proteins in regulating vertebrate ocular development and implicating SOXC mutations in human ocular malformations.
成熟功能性眼睛的形成需要一系列复杂的细胞增殖、迁移、不同胚层间的诱导以及细胞分化过程。这些过程由细胞外信号如Wnt/BMP/Hh/Fgf信号通路以及决定细胞命运的细胞内源性转录因子调控。在这篇综述文章中，我们概述了胚胎眼形态发生的阶段、每个阶段所需的外在和内在因素，以及与眼睛发育缺陷相关的儿科眼部疾病。此外，我们重点关注了SOXC蛋白在调节脊椎动物眼部发育中的作用以及SOXC突变与人类眼部畸形关系的最新研究发现。
