Yuan Xun, Wu Hua, Han Na, Xu Hanxiao, Chu Qian, Yu Shiying, Chen Yuan, Wu Kongming
Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Building 303, 1095 Jie Fang Avenue, Wuhan, 430030, P.R. China.
J Hematol Oncol. 2014 Dec 5;7:87. doi: 10.1186/s13045-014-0087-z.
Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application.
通过上皮-间质转化（EMT），癌细胞获得了更强的迁移和侵袭能力、干细胞样特性以及治疗抗性。Notch信号在器官发育过程中调节细胞间连接、细胞极性和运动性。最近的研究表明，Notch信号在肺癌起始中起重要作用，并与多种转录因子相互作用以增强EMT，促进非小细胞肺癌（NSCLC）的进展。相应地，阻断Notch信号可通过逆转EMT来抑制NSCLC的迁移和肿瘤生长。临床试验已显示，Notch1抑制剂治疗在一些癌症患者中具有良好效果。本综述旨在概述NSCLC中的Notch信号：其生物学意义和治疗应用。
