Ghosh S, Thakurta G G, Mukherjee K L
Indian J Med Res. 1989 Apr;90:147-53.
The glycogen content, and its structure and the enzymes involved in glycogenolysis in human foetal organs were studied at different periods of gestation. Of all the tissues studied glycogen content was found to be the highest in cardiac muscle. Very little glycogen was present in the foetal liver at 9-12 wk of gestation, this increased progressively to nearly 2 per cent at 24 wk. Glycogen content of placenta was lower than that of skeletal muscle and liver. The level of glycogen in adipose tissue, placenta and cerebrum was not high enough to play any role in glucose homeostasis of the foetus. Human foetal liver and skeletal muscle glycogen showed the normal branched structure while the liver glycogen was found to be unusually stable. Glycogen phosphorylase activity in the foetal liver and muscle was found to be low, i.e., about a fifth and a fourth of adult liver and muscle activity respectively. The stability of foetal liver glycogen and phosphorolytic activity in the liver and muscle indicate negligible glycogenolysis during foetal development. Glucose-6-phosphatase activity in foetal liver was undetectable below 12 wk of gestation, the activity increasing progressively up to 24 wk.
在妊娠不同时期，对人类胎儿器官中的糖原含量、其结构以及参与糖原分解的酶进行了研究。在所有研究的组织中，发现心肌中的糖原含量最高。妊娠9至12周时，胎儿肝脏中糖原含量极少，到24周时逐渐增加至近2%。胎盘的糖原含量低于骨骼肌和肝脏。脂肪组织、胎盘和大脑中的糖原水平不足以在胎儿的葡萄糖稳态中发挥任何作用。人类胎儿肝脏和骨骼肌糖原呈现正常的分支结构，而肝脏糖原被发现异常稳定。胎儿肝脏和肌肉中的糖原磷酸化酶活性较低，即分别约为成人肝脏和肌肉活性的五分之一和四分之一。胎儿肝脏糖原的稳定性以及肝脏和肌肉中的磷酸解活性表明，胎儿发育期间糖原分解可忽略不计。妊娠12周以下胎儿肝脏中未检测到葡萄糖-6-磷酸酶活性，该活性在24周时逐渐增加。
