Sontakke Alka N, Tilak Mona A, Dhat Vaishali V, More Umesh M, Shinde Sarita A, Phalak Pradnya, Deshmukh Anita D
Professor and Head, Department of Biochemistry, MIMER Medical College , Talegaon Dabhade, Pune, India .
Professor and Head, Department of Biochemistry, Dr D Y Patil Medical College Pimpri , Pune, India .
J Clin Diagn Res. 2014 Oct;8(10):CC13-5. doi: 10.7860/JCDR/2014/9607.4995. Epub 2014 Oct 20.
Recent studies indicate that the risk of coronary artery disease (CAD) in women is no less than that in men and menopausal women are equally vulnerable as men. Studies of recent risk factors like hyperhomocysteinemia and elevation in lipoprotein (a) reveal controversial role of the same. This study hence is an attempt to study the prevalence of these factors in women and their correlation with lipid profile.
Two hundred women were enrolled in the study- 100 premenopausal women (21-45y) and 100 menopausal (50-55y). All the subjects were screened for homocysteine by ELISA and lipoprotein (a) and lipid profile by automation.
Prevalence of hyperhomocysteinemia was 52% and 62% in premenopausal and menopausal women respectively. A significant positive correlation was seen for total cholesterol and triacylglycerol with serum Homocysteine in premenopausal women while pronounced positive correlation for serum cholesterol with serum Homocysteine in menopausal women. The prevalence of elevated lipoprotein (a) was 42% and 45% in premenopausal and menopausal women respectively. There was no correlation between lipoprotein (a) and lipid profile in both groups.
The findings of the study conclude that premenopausal and menopausal women constitute a subpopulation where recent risk factors like hyperhomocysteinemia and elevated lipoprotein(a) could be assessed along with lipid profile as screening tests to identify the risk of CAD. This would help in proper counselling of the concerned women and minimize the risk.
近期研究表明，女性患冠状动脉疾病（CAD）的风险不亚于男性，绝经后女性与男性同样易患此病。对高同型半胱氨酸血症和脂蛋白（a）升高这些近期风险因素的研究显示，它们的作用存在争议。因此，本研究旨在探讨这些因素在女性中的患病率及其与血脂谱的相关性。
本研究纳入了200名女性，其中100名绝经前女性（21 - 45岁）和100名绝经后女性（50 - 55岁）。所有受试者均通过酶联免疫吸附测定法（ELISA）筛查同型半胱氨酸，并通过自动化检测脂蛋白（a）和血脂谱。
绝经前和绝经后女性高同型半胱氨酸血症的患病率分别为52%和62%。绝经前女性中，总胆固醇和三酰甘油与血清同型半胱氨酸呈显著正相关；绝经后女性中，血清胆固醇与血清同型半胱氨酸呈明显正相关。绝经前和绝经后女性脂蛋白（a）升高的患病率分别为42%和45%。两组中脂蛋白（a）与血脂谱均无相关性。
该研究结果表明，绝经前和绝经后女性构成了一个亚人群，在这个群体中，高同型半胱氨酸血症和脂蛋白（a）升高这些近期风险因素可与血脂谱一起作为筛查试验，以评估患CAD的风险。这将有助于对相关女性进行适当的咨询，并将风险降至最低。
