Pathade Smita C, Kurpad Ramkumar, Narayanan Manoj, Sasikumar V K, Jadhav S S
Associate Professor, Department of Pathology, DM WIMS , Wayanad, Kerala, India .
Professor and HOD, Department of Pathology, DM WIMS , Wayanad, Kerala, India .
J Clin Diagn Res. 2014 Oct;8(10):FD03-5. doi: 10.7860/JCDR/2014/9529.4936. Epub 2014 Oct 20.
Burkitt's lymphoma(BL) is a highly aggressive B -cell Lymphoma of childhood with a doubling time of 24 to 48 h. Depending upon the clinical and epidemiological factors it is classified as Epidemic, Sporadic and Immunodeficiency associated Burkitt's lymphoma. Sporadic Burkitt's lymphoma has its own characteristics with few differences pertaining to specific geographical location. Here, we present a case of 14-year-old boy who presented with advanced stage disease. On examination he had cervical lymphadenopathy and CNS involvement in the form of nerve palsy.USG revealed multiple well defined solid lesions in liver, both kidneys and pancreas. However, PBS did not show the presence of lymphomatous cells. Fine needle aspiration cytology (FNAC) of cervical lymph node and liver lesion showed features suggestive of Burkitt's lymphoma, which was further confirmed on Histopathological and immunohistochemical examination.
伯基特淋巴瘤(BL)是一种侵袭性很强的儿童B细胞淋巴瘤,倍增时间为24至48小时。根据临床和流行病学因素,它被分为流行性、散发性和免疫缺陷相关性伯基特淋巴瘤。散发性伯基特淋巴瘤有其自身特点,在特定地理位置方面存在一些差异。在此,我们报告一例14岁男孩,其表现为晚期疾病。检查发现他有颈部淋巴结病,且以神经麻痹的形式出现中枢神经系统受累。超声检查显示肝脏、双肾和胰腺有多个边界清晰的实性病变。然而,外周血涂片未显示存在淋巴瘤细胞。颈部淋巴结和肝脏病变的细针穿刺细胞学检查(FNAC)显示出提示伯基特淋巴瘤的特征,经组织病理学和免疫组化检查进一步证实。