Lamb J, Anderson T J
Department of Pathology, University of Edinburgh, Scotland.
J Clin Pathol. 1989 Jul;42(7):733-5. doi: 10.1136/jcp.42.7.733.
Fine needle aspiration (FNA) cytology carried out on 1318 primary breast cancers from 1980 to 1986 inclusive showed that 198 were well recognised, histological special types. These included medullary, mucoid, tubular, cribriform and lobular invasive cancers, and non-invasive cancers. Excluding these special histological types, the overall number successfully identified (malignant plus suspicious) by fine needle aspiration was 940 (84%), although in only 820 (73%) was malignancy definitely diagnosed. The results for the special types were variable, the mucoid and medullary cancers being consistently identified while the other types were not. For tubular and cribriform, lobular and non-invasive ductal cancers a malignant diagnosis was made in 30% to 40% of cases, although inclusion of suspicious results gave identification figures of 60% to 70%. Particular cytological patterns are characteristic of some special histological cancer types but lesion cellularity, size, and physical definition are all intrinsic factors influencing success of FNA diagnosis. About 10% of all primary breast cancers seem to have certain histological properties which further reduce the success of fine needle aspiration.
对1980年至1986年（含）期间的1318例原发性乳腺癌进行的细针穿刺（FNA）细胞学检查显示，其中198例为公认的组织学特殊类型。这些类型包括髓样癌、黏液癌、管状癌、筛状癌和小叶浸润性癌以及非浸润性癌。排除这些特殊组织学类型后，细针穿刺成功识别出的总数（恶性加可疑）为940例（84%），不过其中只有820例（73%）被明确诊断为恶性。特殊类型的结果各不相同，黏液癌和髓样癌始终能够被识别出来，而其他类型则不然。对于管状癌、筛状癌、小叶癌和非浸润性导管癌，30%至40%的病例被诊断为恶性，不过将可疑结果包括在内时，识别率为60%至70%。某些特殊组织学癌症类型具有特定的细胞学模式，但病变的细胞密度、大小和物理清晰度都是影响FNA诊断成功率的内在因素。所有原发性乳腺癌中约10%似乎具有某些组织学特征，这进一步降低了细针穿刺的成功率。
