Verdier M, Denis F, Sangaré A, Barin F, Gershy-Damet G, Rey J L, Soro B, Léonard G, Mounier M, Hugon J
Bacteriology-Virology Department, CHU Dupuytren, Limoges, France.
J Infect Dis. 1989 Sep;160(3):363-70. doi: 10.1093/infdis/160.3.363.
A large cross-sectional serologic survey for human T cell leukemia virus type 1 (HTLV-1) antibody was conducted in 3,177 Ivory Coast residents to evaluate the prevalence of HTLV-1 and to determine possible risk factors and correlates of HTLV-1 infection. Of the 3,177 serum samples, 110 (3.5%) were positive for antibody to HTLV-1 by indirect immunofluorescence assay and Western blot. The prevalence of HTLV-1 antibody in the general adult population was 1.8% and increased significantly with age. No difference between males (1.5%) and females (2%) was found. The highest prevalences were observed in female prostitutes (7.4%), patients with neurologic syndromes (5.8%), and lepers (13.7%). The high prevalence of HTLV-1 infection in prostitutes suggests that heterosexual contact is involved in the transmission of HTLV-1 and that prostitutes could play an important role in the spread of the virus in Africa. The high prevalence of HTLV-1 in patients with neurologic syndromes confirms the association between HTLV-1 and some type of neuropathies, as has been observed in the West Indies and Japan. The high prevalence observed in lepers deserves further investigation to find the cause of the association. Twenty-five individuals, including prostitutes, were coinfected with HTLV-1 and human immunodeficiency virus (HIV). Prospective studies are necessary to evaluate the exact role of HTLV-1 alone or in combination with HIV in inducing specific diseases.
对3177名科特迪瓦居民进行了一项大规模的横断面血清学调查，以检测人类T细胞白血病病毒1型（HTLV-1）抗体，评估HTLV-1的流行情况，并确定HTLV-1感染的可能危险因素及相关因素。在3177份血清样本中，有110份（3.5%）通过间接免疫荧光试验和蛋白质印迹法检测出HTLV-1抗体呈阳性。HTLV-1抗体在普通成年人群中的流行率为1.8%，且随年龄显著增加。未发现男性（1.5%）和女性（2%）之间存在差异。在女性性工作者（7.4%）、患有神经综合征的患者（5.8%）和麻风病人（13.7%）中观察到最高的流行率。性工作者中HTLV-1感染的高流行率表明异性接触参与了HTLV-1的传播，并且性工作者可能在非洲该病毒的传播中发挥重要作用。HTLV-1在患有神经综合征的患者中的高流行率证实了HTLV-1与某些类型神经病变之间的关联，正如在西印度群岛和日本所观察到的那样。在麻风病人中观察到的高流行率值得进一步调查以找出这种关联的原因。包括性工作者在内的25人同时感染了HTLV-1和人类免疫缺陷病毒（HIV）。有必要进行前瞻性研究，以评估单独的HTLV-1或与HIV联合在引发特定疾病中的确切作用。
