• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hypoxia promotes stem cell-like phenotype in multiple myeloma cells.

作者信息

Muz B, de la Puente P, Azab F, Luderer M, Azab A K

机构信息

Department of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.

出版信息

Blood Cancer J. 2014 Dec 5;4(12):e262. doi: 10.1038/bcj.2014.82.

DOI:10.1038/bcj.2014.82
PMID:25479569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4315888/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/127f/4315888/4afceb7b3370/bcj201482f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/127f/4315888/31e3ad4b0041/bcj201482f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/127f/4315888/4afceb7b3370/bcj201482f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/127f/4315888/31e3ad4b0041/bcj201482f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/127f/4315888/4afceb7b3370/bcj201482f2.jpg

相似文献

1
Hypoxia promotes stem cell-like phenotype in multiple myeloma cells.缺氧促进多发性骨髓瘤细胞中的干细胞样表型。
Blood Cancer J. 2014 Dec 5;4(12):e262. doi: 10.1038/bcj.2014.82.
2
Concise review: Defining and targeting myeloma stem cell-like cells.简要综述：定义并靶向骨髓瘤干细胞样细胞。
Stem Cells. 2014 May;32(5):1067-73. doi: 10.1002/stem.1643.
3
Identification of tumor stem-like cells in a mouse myeloma cell line.小鼠骨髓瘤细胞系中肿瘤干细胞样细胞的鉴定
Cell Mol Biol (Noisy-le-grand). 2009 Aug 5;55 Suppl:OL1151-60.
4
[Identification and targeting of multiple myeloma stem cells].[多发性骨髓瘤干细胞的鉴定与靶向治疗]
Nihon Rinsho. 2015 May;73(5):816-22.
5
Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma.骨髓瘤干细胞概念、多发性骨髓瘤的异质性与可塑性
Br J Haematol. 2014 Aug;166(3):466-7. doi: 10.1111/bjh.12873. Epub 2014 Apr 2.
6
The myeloma stem cell concept, revisited: from phenomenology to operational terms.骨髓瘤干细胞概念再探讨：从现象学到操作定义
Haematologica. 2016 Dec;101(12):1451-1459. doi: 10.3324/haematol.2015.138826. Epub 2016 Nov 10.
7
Angiogenic activity of mesenchymal stem cells in multiple myeloma.骨髓基质细胞在多发性骨髓瘤中的血管生成活性。
Cancer Invest. 2011 Jan;29(1):37-41. doi: 10.3109/07357907.2010.496758.
8
A serum-free culture method for myeloma progenitors in vitro: proliferative and immunophenotypic characteristics.
Exp Hematol. 1990 Feb;18(2):79-83.
9
[Emergence of cancer stem cells or tumor-initiating/propagating cells and relapse in multiple myeloma].[癌症干细胞或肿瘤起始/增殖细胞的出现与多发性骨髓瘤的复发]
Bull Cancer. 2014 Dec;101(12):1074-9. doi: 10.1684/bdc.2014.2027.
10
Presence of Hoechst low side populations in multiple myeloma.多发性骨髓瘤中Hoechst低侧群的存在
Leuk Lymphoma. 2008 Sep;49(9):1813-6. doi: 10.1080/10428190802272676.

引用本文的文献

1
Unraveling the Binding Mode of TSC2-Rheb through Protein Docking and Simulations.通过蛋白质对接和模拟解析TSC2-Rheb的结合模式
Biochemistry. 2025 Mar 4;64(5):1006-1019. doi: 10.1021/acs.biochem.4c00562. Epub 2025 Feb 13.
2
Development of Hemispherical 3D Models of Human Brain and B Cell Lymphomas Using On-Chip Cell Dome System.使用芯片上细胞穹顶系统构建人脑和B细胞淋巴瘤的半球形3D模型
Bioengineering (Basel). 2024 Dec 23;11(12):1303. doi: 10.3390/bioengineering11121303.
3
Focal adhesion kinase as a new player in the biology of onco-hematological diseases: the starting evidence.

本文引用的文献

1
Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia.缺氧促进华氏巨球蛋白血症中新骨髓微环境中的播散和定植。
Mol Cancer Res. 2015 Feb;13(2):263-72. doi: 10.1158/1541-7786.MCR-14-0150. Epub 2014 Sep 17.
2
Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells.蛋白酶体抑制剂MG-132诱导的活性氧生成增加对Tca-8113细胞中XBP1基因表达及细胞凋亡的影响
Biomed Pharmacother. 2014 Jul;68(6):709-13. doi: 10.1016/j.biopha.2014.07.011. Epub 2014 Jul 18.
3
Molecularly targeted therapies in multiple myeloma.
粘着斑激酶作为血液肿瘤疾病生物学中的新角色：初步证据
Front Oncol. 2024 Aug 30;14:1446723. doi: 10.3389/fonc.2024.1446723. eCollection 2024.
4
Pathways to therapy resistance: The sheltering effect of the bone marrow microenvironment to multiple myeloma cells.治疗耐药途径：骨髓微环境对多发性骨髓瘤细胞的庇护作用。
Heliyon. 2024 Jun 14;10(12):e33091. doi: 10.1016/j.heliyon.2024.e33091. eCollection 2024 Jun 30.
5
Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures.髓外多发性骨髓瘤患者骨髓和血浆的蛋白质组学与代谢组学分析确定了独特的蛋白质和代谢物特征。
Cancers (Basel). 2023 Jul 25;15(15):3764. doi: 10.3390/cancers15153764.
6
Extracellular vesicles released during hypoxia transport heparanase and enhance macrophage migration, endothelial tube formation and cancer cell stemness.缺氧期间释放的细胞外囊泡运输乙酰肝素酶并增强巨噬细胞迁移、内皮管形成和癌细胞干性。
Proteoglycan Res. 2023 Jan 1;1(1). doi: 10.1002/pgr2.1. Epub 2023 Mar 28.
7
Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma.缺氧诱导的氧化应激通过上调多发性骨髓瘤中的血红素加氧酶-1促进治疗抵抗。
Cancer Med. 2023 Apr;12(8):9709-9722. doi: 10.1002/cam4.5679. Epub 2023 Feb 12.
8
An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma.mTORC1 至 HRI 信号轴促进多发性骨髓瘤中蛋白酶体抑制剂的细胞毒性。
Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4.
9
Ca Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression.钙信号转导与缺氧/酸性肿瘤微环境在肿瘤演进中的相互作用。
Int J Mol Sci. 2022 Jul 2;23(13):7377. doi: 10.3390/ijms23137377.
10
Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene.鉴定半胱氨酸蛋白酶组织蛋白酶 L 为潜在的慢性缺氧特异性多发性骨髓瘤靶基因。
Cells. 2022 Jan 15;11(2):292. doi: 10.3390/cells11020292.
多发性骨髓瘤的分子靶向治疗
Leuk Res Treatment. 2014;2014:976567. doi: 10.1155/2014/976567. Epub 2014 Apr 16.
4
The role of P-glycoprotein in drug resistance in multiple myeloma.P-糖蛋白在多发性骨髓瘤耐药中的作用。
Leuk Lymphoma. 2015 Jan;56(1):26-33. doi: 10.3109/10428194.2014.907890. Epub 2014 Jun 5.
5
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells.缺氧降低骨髓瘤细胞中 CD138 的表达，并诱导其呈现幼稚和干细胞样的转录程序。
Int J Oncol. 2013 Dec;43(6):1809-16. doi: 10.3892/ijo.2013.2134. Epub 2013 Oct 10.
6
Clonogenic multiple myeloma cells have shared stemness signature associated with patient survival.克隆形成性多发性骨髓瘤细胞具有与患者生存相关的共同干性特征。
Oncotarget. 2013 Aug;4(8):1230-40. doi: 10.18632/oncotarget.1145.
7
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.缺氧通过获得上皮间质转化样特征促进多发性骨髓瘤的扩散。
Blood. 2012 Jun 14;119(24):5782-94. doi: 10.1182/blood-2011-09-380410. Epub 2012 Mar 6.
8
Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model.5T33多发性骨髓瘤模型中CD138 -和CD138 +肿瘤细胞的肿瘤起始能力。
Leukemia. 2012 Jun;26(6):1436-9. doi: 10.1038/leu.2011.373. Epub 2012 Jan 6.
9
Perspective: A model disease.观点：一种典型疾病。
Nature. 2011 Dec 14;480(7377):S58. doi: 10.1038/480S58a.
10
Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138(+) cells.低骨髓氧张力和缺氧诱导因子-1α过表达是多发性骨髓瘤患者的特征：对CD138(+)细胞转录和促血管生成谱的作用。
Leukemia. 2010 Nov;24(11):1967-70. doi: 10.1038/leu.2010.193. Epub 2010 Sep 2.