Yamamoto H, Yamamoto I
Laboratory of Pathology, Kohno Clinical Medicine Research Institute, Tokyo, Japan.
Exp Toxicol Pathol. 1994 Dec;46(6):453-5. doi: 10.1016/S0940-2993(11)80059-X.
Malignant fibrous histiocytoma (MFH) developed spontaneously in the subcutaneous tissue of the hind leg of a 7-month-old female ddY mouse. Histologically, an original tumor was composed of an admixture of fibroblast-like and histiocyte-like cells arranged in predominantly storiform or cartwheel pattern. The tumor was serially transplanted into syngeneic mice up to the 70th generation. Moreover, the tumor was also consistently transplanted into allogeneic mice of several inbred strains. Allogeneic mice used in the present study were 7 strains having the different H-2 haplo-types. During succeeding passages, transplanted tumor pieces showed aberrant growth properties. Histopathological features of these tumors were basically similar to original tumors. As mentioned above, a spontaneous MFH in the ddY mouse was consistently transplantable into both syngeneic and allogeneic mice. The tumor was designated S-MFH-1T.
一只7个月大的雌性ddY小鼠后肢皮下组织自发形成恶性纤维组织细胞瘤（MFH）。组织学上，原发肿瘤由成纤维细胞样和组织细胞样细胞混合组成，主要呈车轮状或涡状排列。该肿瘤连续移植至同基因小鼠达第70代。此外，该肿瘤也持续移植至几种近交系的异基因小鼠。本研究中使用的异基因小鼠为7个具有不同H-2单倍型的品系。在后续传代过程中，移植的肿瘤块表现出异常生长特性。这些肿瘤的组织病理学特征与原发肿瘤基本相似。如上所述，ddY小鼠中的自发性MFH可连续移植至同基因和异基因小鼠。该肿瘤被命名为S-MFH-1T。
