Camara Ce, Zhou Lin-Yuan, Ma Yan, Zhu Lin, Yu Dong, Zhao Yao-Wu, Yang Nian-Hong
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China.
Key Lab of Environment and Health of the Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Dec;34(6):825-829. doi: 10.1007/s11596-014-1360-7. Epub 2014 Dec 6.
This study was aimed to examine the effect of ovariectomy on visceral fat, serum adiponectin levels and lipid profile. Forty-five female Sprague Dawley rats were divided into three groups (n=15 each): ovariectomized group (OVX), ovariectomized plus estrogen-treated group (OVX+E2), and sham-operated group (SHAM). Body weight, abdominal adipose tissues, serum adiponectin and lipid profile were measured and compared among the groups after three-month feeding post-surgery. Significant increases in body weight and visceral fat were found in ovariectomized rats when compared with sham-operated ones and significant increases were also observed in serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in ovariectomized rats. Body weight, visceral fat and serum adiponectin levels were profoundly reduced in OVX+E2 group as compared with OVX group. It was concluded that ovarian hormone deficiency induced by ovariectomy leads to significant increases in body weight and visceral fat, along with increased serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in rats. Attenuation in these changes can be achieved by estrogen supplementation.
本研究旨在探讨卵巢切除对内脏脂肪、血清脂联素水平及脂质谱的影响。45只雌性斯普拉格-道利大鼠被分为三组（每组n = 15）：卵巢切除组（OVX）、卵巢切除加雌激素治疗组（OVX + E2）和假手术组（SHAM）。术后喂养三个月后，测量并比较各组的体重、腹部脂肪组织、血清脂联素和脂质谱。与假手术大鼠相比，卵巢切除大鼠的体重和内脏脂肪显著增加，且卵巢切除大鼠的血清脂联素、甘油三酯和极低密度脂蛋白胆固醇水平也显著升高。与OVX组相比，OVX + E2组的体重、内脏脂肪和血清脂联素水平显著降低。得出结论，卵巢切除所致的卵巢激素缺乏导致大鼠体重和内脏脂肪显著增加，同时血清脂联素、甘油三酯和极低密度脂蛋白胆固醇水平升高。补充雌激素可减轻这些变化。
