Shirazpour Sara, Khaksari Mohammad, Gaini Abbas Ali, Bashiri Hamideh, Khoramipour Kayvan, Rafie Forouzan
Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Basic Med Sci. 2025;28(6):718-727. doi: 10.22038/ijbms.2025.82005.17745.
Following our previous studies on the anti-obesity and cardioprotective effects of 17-beta estradiol (E2), this study was designed to determine the effects of Resisted swimming (RSW) training and E2 (alone and in combination) on cardiometabolic risk factors in an obese postmenopausal rat model.
Female ovariectomized rats (OVX) were given a standard diet (SD) or a 60% high-fat diet (HFD) for 16 weeks and were divided into two groups: SD and HFD. The rats were divided into ten groups to assess the effects of 8 weeks of E2 (1 mg/kg, IP) administration and RSW (5 days a week) on cardiometabolic risk factors. Parameters including body weight, BMI, visceral fat, blood glucose (BG), and cardiac oxidative stress were assessed 72 hr after the last swimming session.
HFD increased body weight, BMI, visceral fat, and BG levels in OVX rats. Additionally, it negatively affected the lipid profile and cardiac oxidative stress, but both E2 and RSW reduced these parameters in HFD-fed OVX rats. Although RSW and E2 equally prevented these changes, swimming was more effective than estrogen in increasing HDL levels in the SD group. The combination of E2 and RSW had a more significant effect on modulating glucose, TAC, TG, and HDL indices than the individual treatments.
Overall, RSW ameliorates cardiometabolic risk factors in postmenopausal conditions caused by obesity, probably by modulating cardiac oxidative stress. It is also an effective non-pharmacological treatment for E2 substitution.
继我们之前关于17-β雌二醇（E2）的抗肥胖和心脏保护作用的研究之后，本研究旨在确定抗阻游泳（RSW）训练以及E2（单独使用和联合使用）对肥胖绝经后大鼠模型心脏代谢危险因素的影响。
对雌性去卵巢大鼠（OVX）给予标准饮食（SD）或60%高脂饮食（HFD）16周，然后分为两组：SD组和HFD组。将大鼠分为十组，以评估8周给予E2（1 mg/kg，腹腔注射）和RSW（每周5天）对心脏代谢危险因素的影响。在最后一次游泳训练后72小时评估包括体重、体重指数、内脏脂肪、血糖（BG）和心脏氧化应激等参数。
HFD增加了OVX大鼠的体重、体重指数、内脏脂肪和BG水平。此外，它对血脂谱和心脏氧化应激产生负面影响，但E2和RSW均降低了HFD喂养的OVX大鼠的这些参数。尽管RSW和E2同样能预防这些变化，但在SD组中，游泳在提高HDL水平方面比雌激素更有效。E2和RSW联合使用在调节血糖、总抗氧化能力（TAC）、甘油三酯（TG）和HDL指数方面比单独治疗有更显著的效果。
总体而言，RSW可能通过调节心脏氧化应激改善肥胖引起的绝经后状态下的心脏代谢危险因素。它也是一种有效的E2替代非药物治疗方法。
