Centre of Research and Promotion of Women's Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Int J Obes (Lond). 2010 Aug;34(8):1265-74. doi: 10.1038/ijo.2010.33. Epub 2010 Mar 2.
Whether age or menopause per se influences fat distribution remains controversial. This study aimed to investigate the change of body composition, particularly body fat distribution, in relation to menopausal transition in a 30-month prospective study of perimenopausal women.
A total of 438 community-based healthy women aged 44-55 years participated in the Hong Kong Perimenopausal Women Osteoporosis Study. Data were obtained at baseline, and at 9-, 18- and 30-month during the follow-up. Soft tissue measurements consisting of fat mass and lean muscle mass of the trunk and whole body were obtained by the dual energy X-ray absorptiometry. Percentage change of body measurements over the follow-up period was compared between women who remained premenopausal, those who went through menopausal transition, and those who were menopausal since baseline.
A slight decrease in the lean mass but an increase in the total fat mass and trunk fat mass (TFM) over the follow-up period were noted. Multivariate linear regression analysis showed that age was negatively associated with an increase in central obesity. Adjusted for the important predictors--age, age of menarche and education level, menopausal status was a significant and independent predictor of the decrease in lean mass and the increase in percent of body fat, TFM and trunk-leg fat mass ratio.
Our 30-month longitudinal study showed that menopause has an independent effect on an increase in fat mass, and an increase in central obesity in perimenopausal Chinese women.
年龄或绝经本身是否会影响脂肪分布仍存在争议。本研究旨在通过一项为期 30 个月的围绝经期女性前瞻性研究，调查绝经过渡期间身体成分（尤其是体脂分布）的变化。
共有 438 名年龄在 44-55 岁之间的社区健康女性参加了香港围绝经期妇女骨质疏松症研究。基线时、随访 9、18 和 30 个月时获得数据。通过双能 X 射线吸收法获得躯干和全身的脂肪量和瘦肌肉量等软组织测量值。将在随访期间身体测量值的百分比变化与仍处于绝经前、经历绝经过渡和自基线以来已绝经的女性进行比较。
在随访期间，瘦肌肉量略有下降，但总脂肪量和躯干脂肪量（TFM）增加。多变量线性回归分析表明，年龄与中心性肥胖的增加呈负相关。调整重要预测因素——年龄、初潮年龄和教育程度后，绝经状态是瘦肌肉量减少和体脂肪百分比、TFM 和躯干-腿部脂肪质量比增加的显著独立预测因素。
我们的 30 个月纵向研究表明，绝经对围绝经期中国女性脂肪量增加和中心性肥胖增加有独立影响。
