钙黏着蛋白作为神经元极性的调节因子。
Cadherins as regulators of neuronal polarity.
作者信息
Gärtner Annette, Fornasiero Eugenio F, Dotti Carlos G
机构信息
a VIB Center for the Biology of Disease; KULeuven Center for Human Genetics ; Leuven ; Belgium and KULeuven; Department of Development and Regeneration ; Leuven , Belgium.
出版信息
Cell Adh Migr. 2015;9(3):175-82. doi: 10.4161/19336918.2014.983808. Epub 2014 Nov 14.
Abstract
A compelling amount of data is accumulating about the polyphonic role of neuronal cadherins during brain development throughout all developmental stages, starting from the involvement of cadherins in the organization of neurulation up to synapse development and plasticity. Recent work has confirmed that specifically N-cadherins play an important role in asymmetrical cellular processes in developing neurons that are at the basis of polarity. In this review we will summarize recent data, which demonstrate how N-cadherin orchestrates distinct processes of polarity establishment in neurons.
摘要
越来越多令人信服的数据表明，神经元钙黏蛋白在大脑发育的所有阶段都发挥着多方面的作用，从钙黏蛋白参与神经胚形成的组织过程，到突触发育和可塑性。最近的研究证实，特别是N-钙黏蛋白在发育中神经元的不对称细胞过程中发挥重要作用，而这些过程是极性的基础。在这篇综述中，我们将总结最近的数据，这些数据展示了N-钙黏蛋白如何协调神经元中极性建立的不同过程。
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