Sundaresan S, Francke U
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Somat Cell Mol Genet. 1989 Jul;15(4):373-6. doi: 10.1007/BF01534976.
The insulin-like growth factor I (IGF-1) mediates the actions of pituitary growth hormone in a variety of tissues. Its receptor (IGF1R) displays considerable structural similarity to the insulin receptor. In humans, the IGF1R gene has been mapped near FES, the cellular counterpart of the feline sarcoma virus transforming gene v-fes, at the q25-q26 region of human chromosome 15 (HSA15). Here, we report the mapping of mouse Igf1r to mouse chromosome 7 (MMU7) by somatic cell hybrid analysis. This result, along with the prior assignment of the loci for mitochondrial isocitrate dehydrogenase and FES to human chromosome 15 and mouse chromosome 7, suggest a conserved autosomal synteny group on the distal long arm of HSA15 and in the center of MMU7.
胰岛素样生长因子I（IGF-1）在多种组织中介导垂体生长激素的作用。其受体（IGF1R）与胰岛素受体在结构上有很大的相似性。在人类中，IGF1R基因已被定位在人类15号染色体（HSA15）q25-q26区域的FES附近，FES是猫肉瘤病毒转化基因v-fes的细胞对应物。在此，我们通过体细胞杂交分析报告了小鼠Igf1r基因定位于小鼠7号染色体（MMU7）。这一结果，连同之前将线粒体异柠檬酸脱氢酶和FES基因座分别定位于人类15号染色体和小鼠7号染色体，提示在HSA15长臂远端和MMU7中心存在一个保守的常染色体同线性群。
