与一种导致禽类骨质石化的病毒相关的持续性病毒DNA合成
Persistent viral DNA synthesis associated with an avian osteopetrosis-inducing virus.
作者信息
Aurigemma R E, Comstock R D, Smith R E
机构信息
Department of Microbiology, Colorado State University, Ft. Collins 80523.
出版信息
Virology. 1989 Aug;171(2):626-9. doi: 10.1016/0042-6822(89)90636-3.
Bone and red blood cell DNA was obtained from MAV-2(O) infected, osteopetrotic chickens and analyzed for the presence of integrated and unintegrated viral DNA. Results indicate that unintegrated MAV-2(O) DNA did not appear until after osteopetrotic lesions were well established. These observations lead us to conclude that, unlike some retroviral diseases, unintegrated viral DNA may not play a significant role in the pathogenesis of MAV-2(O) osteopetrosis. In addition, there was no evidence of a clonally derived tumor in the bone.
从感染MAV-2(O)的骨石化鸡中获取骨骼和红细胞DNA，并分析整合和未整合病毒DNA的存在情况。结果表明，未整合的MAV-2(O) DNA直到骨石化病变充分形成后才出现。这些观察结果使我们得出结论，与某些逆转录病毒疾病不同，未整合的病毒DNA可能在MAV-2(O)骨石化的发病机制中不发挥重要作用。此外，没有证据表明骨骼中存在克隆衍生的肿瘤。
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