5' 禽白血病病毒序列与骨质石化潜能

5' avian leukosis virus sequences and osteopetrotic potential.

作者信息

Robinson H L, Foster R G, Blais B P, Reinsch S S, Newstein M, Shank P R

机构信息

Department of Pathology, University of Massachusetts Medical Center, Worcester 01655.

出版信息

Virology. 1992 Oct;190(2):866-71. doi: 10.1016/0042-6822(92)90927-h.

DOI:10.1016/0042-6822(92)90927-h

PMID:1325711

Abstract

Recombinants of Rous-associated virus-0 and Br21 have been used to localize 5' viral sequences that affect the osteopetrotic potential of avian leukosis viruses. Rous-associated virus-0 is a benign subgroup E virus of endogenous origin that does not cause osteopetrosis. Br21 is a constructed subgroup E virus with high osteopetrotic potential. 5' sequences that affected osteopetrotic potential resided in an 834-bp region near the 5' LTR. Sequence analysis of this region revealed differences between Br21 and RAV-0 in the mRNA leader and codons for MA.

摘要

劳氏相关病毒0（Rous-associated virus-0，RAV-0）与Br21的重组体已被用于定位影响禽白血病病毒骨石化潜力的5'病毒序列。RAV-0是一种内源性起源的良性E亚群病毒，不会引起骨石化。Br21是一种构建的具有高骨石化潜力的E亚群病毒。影响骨石化潜力的5'序列位于5'长末端重复序列（LTR）附近一个834碱基对的区域。该区域的序列分析揭示了Br21与RAV-0在mRNA前导序列和基质蛋白（MA）密码子上的差异。