我们对长链非编码RNA在正常肝功能、疾病及恶性肿瘤中所起作用的新认识。

Mahpour Amin, Mullen Alan C

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Harvard Medical School, Boston, MA 02115, USA.

JHEP Rep. 2020 Sep 3;3(1):100177. doi: 10.1016/j.jhepr.2020.100177. eCollection 2021 Feb.

Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.

长链非编码RNA（lncRNAs）是调节众多细胞过程的重要生物介质。新的实验证据表明，lncRNAs在肝脏发育、正常肝脏生理、纤维化和恶性肿瘤（包括肝细胞癌和胆管癌）中发挥着重要作用。在这篇综述中，我们总结了目前对lncRNAs在肝脏健康和疾病中的功能的理解，并讨论了可用于将这些非编码转录本作为治疗靶点的方法。