Jung Kuk Hyun, Oh Seung Jong, Choi Kang Kook, Kim Su Mi, Choi Min Gew, Lee Jun Ho, Noh Jae Hyung, Sohn Tae Sung, Bae Jae Moon, Kim Sung
Department of Surgery, Bundang Jesaeng Hospital, Seongnam, Korea.
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ann Surg Treat Res. 2014 Dec;87(6):311-8. doi: 10.4174/astr.2014.87.6.311. Epub 2014 Nov 28.
Surgical site infection (SSI) after open abdominal surgery is still a frequently reported nosocomial infection. To reduce the incidence of SSI, triclosan-coated sutures with antiseptic activity (Vicryl Plus) were developed. The aim of this study was to analyze the effect of Vicryl Plus on SSI after gastric cancer surgery via midline laparotomy.
A total of 916 patients who underwent gastric cancer surgery at Samsung Medical Center between December 2009 and September 2011 were prospectively collected. We examined the occurrence of SSI (primary endpoint), assessments of wound healing (secondary endpoint). They were evaluated postoperatively on days 3, 7, and 30.
Of the 916 patients, 122 were excluded postoperatively by screening (out of the study protocol, adverse events, etc.). The remaining 794 patients were enrolled and monitored postoperatively. The cumulative SSI incidence was 11 cases (1.39%; 95% confidence interval [CI], 0.77-2.50) on day 30. Seromas were most frequently detected in wound healing assessments, with a cumulative incidence of 147 cases (18.51%; 95% CI, 15.98-21.39) on day 30.
The use of triclosan-coated sutures (Vicryl Plus) for abdominal wall closure can reduce the number of SSIs in gastric cancer surgery.
开腹手术后手术部位感染（SSI）仍是一种经常被报道的医院感染。为降低SSI的发生率，研发了具有抗菌活性的三氯生涂层缝线（薇乔加强缝线）。本研究的目的是分析薇乔加强缝线对经正中剖腹术的胃癌手术后SSI的影响。
前瞻性收集了2009年12月至2011年9月在三星医疗中心接受胃癌手术的916例患者。我们检查了SSI的发生情况（主要终点）、伤口愈合评估（次要终点）。在术后第3天、第7天和第30天对患者进行评估。
916例患者中，术后通过筛查排除了122例（不符合研究方案、不良事件等）。其余794例患者被纳入并进行术后监测。在第30天时，累积SSI发生率为11例（1.39%；95%置信区间[CI]，0.77 - 2.50）。在伤口愈合评估中，血清肿最常被检测到，在第30天时累积发生率为147例（18.51%；95%CI，15.98 - 21.39）。
使用三氯生涂层缝线（薇乔加强缝线）进行腹壁缝合可减少胃癌手术中的SSI数量。
