Feedback regulation of mTORC1 by Grb10 in metabolism and beyond.
作者信息
Liu Bilian, Liu Feng
机构信息
a Metabolic Syndrome Research Center; Key Laboratory of Diabetes Immunology; Ministry of Education ; National Clinic Research Center for Metabolic Diseases; The Xiangya Second Hospital ; Central South University ; Changsha , Hunan , China.
出版信息
Cell Cycle. 2014;13(17):2643-4. doi: 10.4161/15384101.2014.954221.
Abstract
摘要
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本文引用的文献
1
Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.Grb10通过对mTORC1的磷酸化依赖性反馈抑制来促进脂肪分解和产热。
Cell Metab. 2014 Jun 3;19(6):967-80. doi: 10.1016/j.cmet.2014.03.018. Epub 2014 Apr 17.
2
What we talk about when we talk about fat.我们谈论脂肪时在谈论什么。
Cell. 2014 Jan 16;156(1-2):20-44. doi: 10.1016/j.cell.2013.12.012.
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mTORC1 status dictates tumor response to targeted therapeutics.mTORC1 状态决定了肿瘤对靶向治疗药物的反应。
Sci Signal. 2013 Sep 24;6(294):pe31. doi: 10.1126/scisignal.2004632.
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A Central role for mTOR in lipid homeostasis.mTOR 在脂质动态平衡中的核心作用。
Cell Metab. 2013 Oct 1;18(4):465-9. doi: 10.1016/j.cmet.2013.08.002. Epub 2013 Aug 22.
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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.磷酸化蛋白质组分析鉴定 Grb10 是 mTORC1 的底物，可负向调节胰岛素信号。
Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484.
6
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.mTOR 调控的磷酸化蛋白质组揭示了 mTORC1 介导的生长因子信号抑制的机制。
Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498.
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Grb10: more than a simple adaptor protein.Grb10：不止是一种简单的衔接蛋白。
Front Biosci. 2004 Jan 1;9:387-403. doi: 10.2741/1226.
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