甲状腺功能亢进和减退状态与痛风密切相关，与高尿酸血症弱相关。
Hyperthyroid and hypothyroid status was strongly associated with gout and weakly associated with hyperuricaemia.
作者信息
See Lai-Chu, Kuo Chang-Fu, Yu Kuang-Hui, Luo Shue-Fen, Chou I-Jun, Ko Yu-Shien, Chiou Meng-Jiun, Liu Jia-Rou
机构信息
Department of Public Health, & Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan.
Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom.
出版信息
PLoS One. 2014 Dec 8;9(12):e114579. doi: 10.1371/journal.pone.0114579. eCollection 2014.
OBJECTIVES
The aim of this study was to estimate the risk of hyperuricaemia and gout in people with hypothyroid or hyperthyroid status.
METHODS
This study analyzed data from individuals who participated in health screening programs at Chang Gung Memorial Hospital in northern Taiwan (2000-2010). Participants were categorized as having euthyroid, hypothyroid, or hyperthyroid status according to their thyroid-stimulating hormone (TSH) levels. Multinomial logistic regression models were used to calculate the odds ratios (95% CI) for hyperuricaemia and gout in participants with thyroid dysfunction compared to euthyroid participants.
RESULTS
A total of 87,813 (euthyroid, 83,502; hypothyroid, 1,460; hyperthyroid, 2,851) participants were included. The prevalence of hyperuricaemia was higher in hyperthyroid subjects (19.4%) than in euthyroid subjects (17.8%) but not in hypothyroid subjects (19.3%). The prevalence of gout was significantly higher in both hypothyroid (6.0%) and hyperthyroid (5.3%) subjects than in euthyroid subjects (4.3%). In men, hypothyroid or hyperthyroid status was not associated with hyperuricaemia. However, hypothyroid or hyperthyroid status was associated with ORs (95% CI) of 1.47 (1.10-1.97) and 1.37 (1.10-1.69), respectively, for gout. In women, hypothyroid status was not associated with hyperuricaemia or gout. However, hyperthyroid status was associated with ORs (95% CI) of 1.42 (1.24-1.62) for hyperuricaemia and 2.13 (1.58-2.87) for gout.
CONCLUSIONS
Both hyperthyroid and hypothyroid status were significantly associated with gout and weakly associated with hyperuricaemia. A thyroid function test for gout patients may by warranted.
目的
本研究旨在评估甲状腺功能减退或亢进人群发生高尿酸血症和痛风的风险。
方法
本研究分析了参与台湾北部长庚纪念医院健康筛查项目（2000 - 2010年）的个体数据。参与者根据促甲状腺激素（TSH）水平分为甲状腺功能正常、减退或亢进状态。采用多项逻辑回归模型计算甲状腺功能异常参与者与甲状腺功能正常参与者相比发生高尿酸血症和痛风的比值比（95%可信区间）。
结果
共纳入87813名参与者（甲状腺功能正常者83502名、甲状腺功能减退者1460名、甲状腺功能亢进者2851名）。甲状腺功能亢进者高尿酸血症患病率（19.4%）高于甲状腺功能正常者（17.8%），但甲状腺功能减退者（19.3%）并非如此。甲状腺功能减退者（6.0%）和甲状腺功能亢进者（5.3%）的痛风患病率均显著高于甲状腺功能正常者（4.3%）。在男性中，甲状腺功能减退或亢进状态与高尿酸血症无关。然而，甲状腺功能减退或亢进状态与痛风的比值比（95%可信区间）分别为1.47（1.10 - 1.97）和1.37（1.10 - 1.69）。在女性中，甲状腺功能减退状态与高尿酸血症或痛风无关。然而，甲状腺功能亢进状态与高尿酸血症的比值比（95%可信区间）为1.42（1.24 - 1.62），与痛风的比值比为2.13（1.58 - 2.87）。
结论
甲状腺功能亢进和减退状态均与痛风显著相关，与高尿酸血症弱相关。痛风患者可能有必要进行甲状腺功能检查。
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