Kim So Young, Yoo Dae Myoung, Kwon Mi Jung, Kim Ji Hee, Kim Joo-Hee, Bang Woo Jin, Kim Sung Kyun, Choi Hyo Geun
Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
J Pers Med. 2022 May 27;12(6):887. doi: 10.3390/jpm12060887.
In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥40 years old in the Korean National Health Insurance Service−Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case−control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the <60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.
在本研究中，我们调查了痛风患者患甲状腺癌的风险。对韩国国民健康保险服务健康筛查队列中年龄≥40岁的参与者进行了调查。总共5844例甲状腺癌患者与23376名对照参与者（无甲状腺癌病史）配对，以建立巢式病例对照研究。从甲状腺癌患者和对照参与者中均收集痛风既往史。使用条件逻辑回归模型分析甲状腺癌与痛风既往史之间的关系。甲状腺癌患者的痛风发生率高于对照组。在整个研究人群中，甲状腺癌与痛风既往史之间的关系在统计学上不明显。痛风既往史与<60岁、体重正常、血压异常且CCI评分=0组的痛风风险增加有关。在一般成年人群中，甲状腺癌的发生与痛风既往史无关。然而，痛风既往史与中年且无合并症的健康人群中甲状腺癌风险升高有关。
