Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, Netherlands.
Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, Netherlands.
Nat Rev Rheumatol. 2015 Mar;11(3):135-45. doi: 10.1038/nrrheum.2014.206. Epub 2014 Dec 9.
Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of infections. This risk has been further increased by the introduction of biologic agents over the past two decades. One of the most effective strategies to prevent infection is vaccination. However, patients with an AIRD have a compromised immune system, which is further impaired by medication. Another important issue is the possibility of triggering a broad nonspecific response by vaccination, potentially resulting in increased activity of the underlying autoimmune disease. In this Review, we provide an analysis of data on vaccination of patients with an AIRD. Both the efficacy and the safety of vaccination are addressed, together with the epidemiology of vaccine-preventable infectious diseases in different subgroups of adults with AIRDs. Special attention is given to vaccination of patients who are treated with biologic agents.
患有自身免疫性炎症性风湿病 (AIRD) 的患者感染的风险增加。在过去的二十年中，生物制剂的引入进一步增加了这种风险。预防感染最有效的策略之一是接种疫苗。然而，患有 AIRD 的患者免疫系统受损，药物进一步削弱了免疫系统。另一个重要问题是接种疫苗可能引发广泛的非特异性反应，从而潜在地导致潜在自身免疫性疾病的活动增加。在这篇综述中，我们对 AIRD 患者接种疫苗的数据进行了分析。同时讨论了疫苗接种的疗效和安全性，以及不同亚组成人 AIRD 患者中可通过疫苗预防的传染病的流行病学。特别关注接受生物制剂治疗的患者的疫苗接种。
