关于感染疫苗接种后自身免疫性疾病患者的文献综述。
A literature review on the patients with autoimmune diseases following vaccination against infections.
作者信息
Liang Yan, Meng Fan-Ya, Pan Hai-Feng, Ye Dong-Qing
机构信息
a Department of Epidemiology and Biostatistics ; School of Public Health; Anhui Medical University ; Hefei , China.
出版信息
Hum Vaccin Immunother. 2015;11(9):2274-80. doi: 10.1080/21645515.2015.1009337.
Abstract
Due to immune abnormalities and the use of steroids and immunosuppressant treatment, patients with rheumatic diseases are susceptible to infections. Vaccination is one of the most important prevention tools in modern medicine. A discussion on risk-benefit or cost-benefit analysis, and advisory on individual vaccines or vaccination programs falls outside the scope of this review. In particularly, this review summarizes the knowledge about the effectiveness and safety vaccinations in patients with autoimmune inflammatory rheumatic diseases (AIIRD) treated with biologics. Finally, we aim to provide vaccination plans basis for clinical management of rheumatic patients depending upon prevaccination antibody titers, drug treatments and immunological potential.
摘要
由于免疫异常以及使用类固醇和免疫抑制治疗，风湿病患者易发生感染。疫苗接种是现代医学中最重要的预防手段之一。关于风险效益或成本效益分析以及针对个别疫苗或疫苗接种计划的建议不在本综述范围内。特别是，本综述总结了接受生物制剂治疗的自身免疫性炎性风湿病（AIIRD）患者疫苗接种的有效性和安全性方面的知识。最后，我们旨在根据接种前抗体滴度、药物治疗和免疫潜力为风湿病患者的临床管理提供疫苗接种计划依据。
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