Yang Tao, Lu Long, Shen Qilong
Key Laboratory of Organofluorine Chemistry Laboratory, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai, 200032, China.
Chem Commun (Camb). 2015 Mar 28;51(25):5479-81. doi: 10.1039/c4cc08655d.
An iron-mediated hydro-trifluoromethylthiolation of unactivated olefins under mild conditions was described for the first time. The reaction occurred to full conversion within 30 min at 0 °C and tolerates a variety of functional groups. Preliminary mechanistic studies suggested that the reaction proceeds via a free-radical pathway.
首次报道了在温和条件下铁介导的未活化烯烃的氢三氟甲硫基化反应。该反应在0℃下30分钟内即可完全转化，并能耐受多种官能团。初步机理研究表明，该反应通过自由基途径进行。
