Castiglione Vincent, Jouret François, Bruyère Olivier, Dubois Bernard, Thomas Alexandre, Waltregny David, Bekaert Anne-Catherine, Cavalier Étienne, Gadisseur Romy
Département de biologie clinique, service de chimie clinique, centre hospitalier universitaire de Liège (ULg CHU), Liège, Belgique.
Département de médecine interne, service de néphrologie, ULg CHU, Liège, Belgique.
Nephrol Ther. 2015 Feb;11(1):42-9. doi: 10.1016/j.nephro.2014.08.003. Epub 2014 Dec 3.
Urolithiasis is a common condition, with a prevalence of ∼10% and a male/female ratio above 1 according to large national series. Various types of urinary stones have been described upon their mineral content and/or their morphology. Hence, a combined morpho-constitutional (M-C) classification has been proposed. In order to detail the prevalence of urolithiasis in general and of each M-C type in particular upon age and gender in Belgium, we retrospectively studied the database of a reference center for urolithiasis analysis. Between 2010 and 2013, 2195 stones were characterized. We excluded 45 non-biological stones and 281 stones, which originated from outside the study zone. Among 1869 stones, 1293 (69.2%) affected men. Prevalence peak of urolithiasis was observed between 50-60 years of age in both genders. The M-C analysis was available for 1854 stones (99.2%): multiple morphological types were concomitantly identified in 49.3%. In the whole population, the main mineral constituent was whewellite (54.4%), mainly organized as type Ia (94%). Weddellite was found in 19.8%, with an equal distribution between types IIa and IIb. Uric acid was the 3rd most frequent constituent in man, with a similar distribution between IIIa and IIIb. Phosphate was uncommon in man (8.2%), but frequent in woman (26.6%) with a type IVa1 organization. Prevalence of M-C types changes with aging, i.e. decrease of weddellite and increase of whewellite and uric acid in both genders. This retrospective analysis of a single-center database of urinary stones helps characterize the M-C epidemiology of urolithiasis in Belgium.
尿路结石是一种常见病症，根据大型全国性研究系列，其患病率约为10%，男性与女性的比例高于1。根据尿结石的矿物质成分和/或形态，已描述了各种类型的尿结石。因此，有人提出了一种形态-结构（M-C）联合分类法。为了详细了解比利时尿路结石的总体患病率以及各M-C类型在年龄和性别方面的具体患病率，我们回顾性研究了一家尿路结石分析参考中心的数据库。2010年至2013年期间，对2195颗结石进行了特征分析。我们排除了45颗非生物结石和281颗来自研究区域以外的结石。在1869颗结石中，1293颗（69.2%）影响男性。在两个性别中，尿路结石的患病率高峰均出现在50至60岁之间。对1854颗结石（99.2%）进行了M-C分析：49.3%的结石同时鉴定出多种形态类型。在整个人口中，主要矿物质成分是草酸钙（54.4%），主要以Ia型组织形式存在（94%）。发现水草酸钙在19.8%的结石中存在，在IIa型和IIb型之间分布均匀。尿酸是男性中第三常见的成分，在IIIa型和IIIb型之间分布相似。磷酸盐在男性中不常见（8.2%），但在女性中常见（26.6%），组织形式为IVa1型。M-C类型的患病率随年龄增长而变化，即两个性别中水草酸钙减少，草酸钙和尿酸增加。对尿路结石单中心数据库的这项回顾性分析有助于描述比利时尿路结石的M-C流行病学特征。
