Samish Ilan, Bourne Philip E, Najmanovich Rafael J
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada.
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada.
Bioinformatics. 2015 Jan 1;31(1):146-50. doi: 10.1093/bioinformatics/btu769. Epub 2014 Dec 8.
The field of structural bioinformatics and computational biophysics has undergone a revolution in the last 10 years. Developments that are captured annually through the 3DSIG meeting, upon which this article reflects.
An increase in the accessible data, computational resources and methodology has resulted in an increase in the size and resolution of studied systems and the complexity of the questions amenable to research. Concomitantly, the parameterization and efficiency of the methods have markedly improved along with their cross-validation with other computational and experimental results.
The field exhibits an ever-increasing integration with biochemistry, biophysics and other disciplines. In this article, we discuss recent achievements along with current challenges within the field.
结构生物信息学和计算生物物理学领域在过去十年经历了一场变革。每年通过3DSIG会议所呈现的发展情况，本文对此有所反映。
可获取数据、计算资源和方法的增加，使得所研究系统的规模和分辨率以及适合研究的问题的复杂性都有所提高。与此同时，这些方法的参数化和效率显著提升，并且与其他计算和实验结果的交叉验证也得到了改善。
该领域与生物化学、生物物理学及其他学科的整合程度不断提高。在本文中，我们讨论了该领域近期的成就以及当前面临的挑战。
