高能喷丸制备的具有纳米形貌的钛表面特征及成骨样细胞的体外行为
Surface characteristics of and in vitro behavior of osteoblast-like cells on titanium with nanotopography prepared by high-energy shot peening.
作者信息
Deng Zhennan, Yin Baodi, Li Weihong, Liu Jinsong, Yang Jingyuan, Zheng Tieli, Zhang Dafeng, Yu Haiyang, Liu Xiaoguang, Ma Jianfeng
机构信息
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China ; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
出版信息
Int J Nanomedicine. 2014 Nov 28;9:5565-73. doi: 10.2147/IJN.S71625. eCollection 2014.
BACKGROUND AND METHODS
Commercial pure titanium with nanotopography was prepared via a high-energy shot-peening (HESP) technique. The surface characteristics were evaluated, and the preliminary cell responses to the nanotopographical surface were investigated.
RESULTS
The nanotopographical surface layer on titanium was successfully processed by HESP. The average nanoscale grains were approximately 60 nm in diameter and they were nonhomogeneously distributed on the surface. MG-63 cells with an osteogenic phenotype were well adhered and well spread on the nanostructured surface. Compared to the original polished control, the nanotopographical surface highly improved the adhesion, viability, and differentiation of MG-63 cells.
CONCLUSION
Titanium with nanotopography achieved by HESP has good cytocompatibility and shows promise for dental implant applications.
背景与方法
采用高能喷丸强化（HESP）技术制备具有纳米拓扑结构的商用纯钛。评估了其表面特性，并研究了细胞对纳米拓扑表面的初步反应。
结果
通过HESP成功地在钛表面加工出纳米拓扑表面层。平均纳米级晶粒直径约为60nm，且在表面分布不均匀。具有成骨表型的MG-63细胞在纳米结构表面上良好粘附且铺展良好。与原始抛光对照相比，纳米拓扑表面显著提高了MG-63细胞的粘附、活力和分化。
结论
通过HESP获得的具有纳米拓扑结构的钛具有良好的细胞相容性，在牙种植体应用方面具有前景。
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