Abenavoli Ludovico, Milic Natasa, Peta Valentina, Alfieri Francesco, De Lorenzo Antonino, Bellentani Stefano
Ludovico Abenavoli, Valentina Peta, Department of Health Sciences, University Magna Graecia, Campus Germaneto, 88100 Catanzaro, Italy.
World J Gastroenterol. 2014 Dec 7;20(45):16831-40. doi: 10.3748/wjg.v20.i45.16831.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The mechanisms of the underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation status, among other possible genetic, dietary, and lifestyle factors, are thought to play the key role. There is no consensus concerning the pharmacological treatment. However, the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy. On the basis of its components, the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases, including obesity and diabetes. New evidence supports the idea that the Mediterranean diet, associated with physical activity and cognitive behaviour therapy, may have an important role in the prevention and the treatment of NAFLD.
非酒精性脂肪性肝病（NAFLD）是全球最常见的肝脏疾病。其潜在疾病发展和进展的机制尚待阐明。胰岛素抵抗和肥胖相关的炎症状态，以及其他可能的遗传、饮食和生活方式因素，被认为起着关键作用。关于药物治疗尚无共识。然而，通过饮食营养管理实现体重减轻是任何治疗策略的重要组成部分。基于其成分，文献报道了地中海饮食在降低心血管风险以及预防包括肥胖和糖尿病在内的主要慢性疾病方面的有效性。新证据支持这样一种观点，即地中海饮食与体育活动和认知行为疗法相结合，可能在NAFLD的预防和治疗中发挥重要作用。
