Sofi Francesco, Casini Alessandro
Francesco Sofi, Alessandro Casini, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
World J Gastroenterol. 2014 Jun 21;20(23):7339-46. doi: 10.3748/wjg.v20.i23.7339.
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in Western countries, being considered as the hepatic manifestation of metabolic syndrome. NAFLD has a common pathogenic background to that of metabolic syndrome, and shares many risk factors such as obesity, hypertension, insulin resistance and dyslipidemia. Although there is no currently available evidence-based established treatment for NAFLD, all the recommendations from the medical associations indicate that the most effective treatment is to reduce weight through lifestyle modifications. Diet, indeed, plays a key role in the management of NAFLD patients, as both the quantity and quality of the diet have been reported to have a beneficial role in the onset and severity of the liver disease. Among all the diets that have been proposed, a Mediterranean diet was the most effective dietary option for inducing weight loss together with beneficial effects on all the risk factors associated with metabolic syndrome and NAFLD. Over the last few years, research has demonstrated a beneficial effect of a Mediterranean diet in NAFLD. In this review, we will examine all the available data on the association between diet, nutrients and the Mediterranean diet in association with onset and severity of NAFLD.
非酒精性脂肪性肝病（NAFLD）是西方国家最常见的慢性肝病，被视为代谢综合征的肝脏表现。NAFLD与代谢综合征有共同的致病背景，且有许多共同的危险因素，如肥胖、高血压、胰岛素抵抗和血脂异常。尽管目前尚无基于证据的NAFLD既定治疗方法，但各医学协会的所有建议均表明，最有效的治疗方法是通过改变生活方式来减轻体重。事实上，饮食在NAFLD患者的管理中起着关键作用，因为据报道，饮食的量和质量在肝病的发生和严重程度方面都具有有益作用。在所有已提出的饮食中，地中海饮食是诱导体重减轻的最有效饮食选择，同时对与代谢综合征和NAFLD相关的所有危险因素都有有益影响。在过去几年中，研究已证明地中海饮食对NAFLD有有益作用。在本综述中，我们将研究关于饮食、营养素以及地中海饮食与NAFLD的发生和严重程度之间关联的所有现有数据。
