The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology , Haifa 3200003, Israel.
Nano Lett. 2015 Feb 11;15(2):1288-95. doi: 10.1021/nl504482t. Epub 2014 Dec 18.
We report on an ultrasensitive, molecularly modified silicon nanowire field effect transistor that brings together the lock-and-key and cross-reactive sensing worlds for the diagnosis of (gastric) cancer from exhaled volatolome. The sensor is able to selectively detect volatile organic compounds (VOCs) that are linked with gastric cancer conditions in exhaled breath and to discriminate them from environmental VOCs that exist in exhaled breath samples but do not relate to the gastric cancer per se. Using breath samples collected from actual patients with gastric cancer and from volunteers who do not have cancer, blind analysis validated the ability of the reported sensor to discriminate between gastric cancer and control conditions with >85% accuracy, irrespective of important confounding factors such as tobacco consumption and gender. The reported sensing approach paves the way to use the power of silicon nanowires for simple, inexpensive, portable, and noninvasive diagnosis of cancer and other disease conditions.
我们报告了一种超灵敏的分子修饰硅纳米线场效应晶体管，它将锁钥和交叉反应传感世界结合在一起，用于从呼气挥发物中诊断（胃癌）。该传感器能够选择性地检测与呼气中胃癌情况相关的挥发性有机化合物（VOCs），并将其与存在于呼气样本中但与胃癌本身无关的环境 VOCs 区分开来。使用从实际胃癌患者和无癌症志愿者收集的呼吸样本进行的盲法分析验证了所报道的传感器能够以 >85%的准确率区分胃癌和对照条件的能力，而不论吸烟和性别等重要混杂因素如何。所报道的传感方法为利用硅纳米线的强大功能进行癌症和其他疾病状况的简单、经济、便携和非侵入性诊断铺平了道路。
